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This Month's Highlights

While an association between obesity and psoriasis (and other chronic inflammatory diseases) has been documented previously, Herbert and colleagues show that the serum level of free fatty acids, rather than obesity, is related to psoriasiform inflammation. In addition, manipulation of dietary saturated fatty acids modulated inflammation in a mouse model. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article on mouse models of psoriasis and ELISA here and here.
Shedding light on the molecular pathogenesis of psoriasis, Mellett and colleagues report that a CARD14 gain-of-function mutation, which has been identified as an autosomal dominant mutation associated with increased susceptibility to psoriasis, is sufficient to induce a chronic psoriatic phenotype driven by the interleukin-23/17 axis in mice. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article on RNAseq .
After identifying the D-series resolvins in skin after injury via a metabolomics approach, Hellman and colleagues report that topical application of these lipid mediators facilitates re-epithelialization and enhances migration of epidermal keratinocytes in wounded skin, indicating a functional role for resolvins in tissue repair.
    • Is CCR6 required for the development of psoriasiform dermatitis in mice?

      Sebastian Yu, Xuesong Wu, Yan Zhou, Dan Han, Leif S. Anderson, Scott I. Simon, Samuel T. Hwang, Yasutomo Imai
      Publication stage: In Press Accepted Manuscript
      Journal of Investigative Dermatology
      Published online: September 4, 2018
    • IFN-γ promotes but dexamethasone dissociates TLR2/1-induced host responses in human macrophages

      Philipp Kröll, Kristin Knoke, Julia Steiger, Mario Fabri
      Publication stage: In Press Accepted Manuscript
      Journal of Investigative Dermatology
      Published online: September 4, 2018
    • Age-dependent transformation of skin biomechanical properties and micromorphology during infancy and childhood

      Joachim W. Fluhr, Gaëlle Bellemère, Chiara Ferrari, Clarence De Belilovsky, Gaëtan Boyer, Nadège Lachmann, Colin P. McGuckin, Nico Forraz, Razvigor Darlenski, Bernard Chadoutaud, Philippe Msika, Caroline Baudouin, Giovanni Pellacani
      Publication stage: In Press Accepted Manuscript
      Journal of Investigative Dermatology
      Published online: September 1, 2018
    • Lineage identity and location within the dermis determine the function of papillary and reticular fibroblasts in human skin

      Ana Korosec, Sophie Frech, Bernhard Gesslbauer, Martin Vierhapper, Christine Radtke, Peter Petzelbauer, Beate M. Lichtenberger
      Publication stage: In Press Accepted Manuscript
      Journal of Investigative Dermatology
      Published online: September 1, 2018
    • IL-22 downregulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis

      Jingyao Liang, Pingjiao Chen, Changxing Li, Dongmei Li, Jianqin Wang, Rujun Xue, Sanquan Zhang, Jianbo Ruan, Xibao Zhang
      Publication stage: In Press Accepted Manuscript
      Journal of Investigative Dermatology
      Published online: August 29, 2018

Most Downloaded JID Articles Published Since 2014

  • Abstract Image

    The Anti-Inflammatory Activities of Propionibacterium acnes CAMP Factor-Targeted Acne Vaccines

    Yanhan Wang, Tissa R. Hata, Yun Larry Tong, Ming-Shan Kao, Christos C. Zouboulis, Richard L. Gallo, Chun-Ming Huang
    Publication stage: In Press Corrected Proof
    Journal of Investigative Dermatology
  • Vaccinating against Acne: Benefits and Potential Pitfalls

    Emmanuel Contassot
    Publication stage: In Press Corrected Proof
    Journal of Investigative Dermatology
  • Abstract Image

    High-Fat Diet Exacerbates Early Psoriatic Skin Inflammation Independent of Obesity: Saturated Fatty Acids as Key Players

    Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C. Simon, Anja Saalbach
    Journal of Investigative Dermatology, Vol. 138, Issue 9
  • Abstract Image

    Filaggrin 2 Deficiency Results in Abnormal Cell-Cell Adhesion in the Cornified Cell Layers and Causes Peeling Skin Syndrome Type A

    Janan Mohamad, Ofer Sarig, Lisa M. Godsel, Alon Peled, Natalia Malchin, Ron Bochner, Dan Vodo, Tom Rabinowitz, Mor Pavlovsky, Shahar Taiber, Maya Fried, Marina Eskin-Schwartz, Siwar Assi, Noam Shomron, Jouni Uitto, Jennifer L. Koetsier, Reuven Bergman, Kathleen J. Green, Eli Sprecher
    Journal of Investigative Dermatology, Vol. 138, Issue 8
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    Risk of Skin Cancer Associated with the Use of UV Nail Lamp

    Alina Markova, Martin A. Weinstock
    Journal of Investigative Dermatology, Vol. 133, Issue 4
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September 2018
Volume 138, Issue 9

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4 September 2018:  Bob Dellavalle of the University of Colorado interviews Adrian Hayday, PhD of King's College London, Celgene Lecturer at IID2018.

26 July 2018:  Table of Contents August 2018 issue of the JID

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