New & Noteworthy

Deal counts, total investment value, deal sizes, and company valuations.

Across >$9 billion invested in dermatology companies from 2002-2021, annual deal counts, total investment value, and the range of deal sizes have increased, while average investment size and post-investment company valuations decreased; funding was largely directed to pharmaceuticals/biotechnology, though historical maximum funding amounts for clinics/outpatient services, health information technology, and medical devices were achieved in 2021.

Articles in Press

Methods and Techniqures in Skin Research
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This Month's Highlights

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Sample collection and gene expression variation of the full-thickness skin.

Yan et al. provide results of transcriptomic analysis based on RNA sequencing of 159 skin samples from head and neck, trunk and extremities, perineum, and palmoplantar regions, demonstrating that human skin exhibits transcriptomic heterogeneity that reflects variation in physiological and developmental processes at the different anatomic sites. The full results are available on an open website.

The p300/CBP HAT inhibitor A485 reduces psoriasis-like skin inflammation.

Kim et al. demonstrate that treatment with selective inhibitors of the histone acetyltransferase domain of p300/CBP reduced expression of several genes known to be upregulated in psoriatic fibroblasts. Treatment with this specific p300/CBP inhibitor reduced psoriasis-like skin inflammation in a murine model, suggesting not only that epigenetic modifications play a crucial role in psoriasis but also that inhibition of p300/CBP is a potential therapeutic strategy.


K75 is a component of the LINC complex and is essential for promoting the SOX2-mediated rapid healing effects.

The transcription factor SOX2 primes oral epithelium for rapid wound repair. Sawaya et al. report that SOX2 regulates K75 expression and that this keratin also becomes a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex to mediate the SOX2 rapid healing response during wound repair.

Resources for Clinical Research in the JID


Society for Investigative Dermatology (SID)

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

European Society for Dermatological Research (ESDR)

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.



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