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Deal counts, total investment value, deal sizes, and company valuations.

Skin in the Game: An Analysis of Venture Capital Investment in Dermatology from 2002 to 2021

Aneesh Agarwal,Seth J. Orlow

Across >$9 billion invested in dermatology companies from 2002-2021, annual deal counts, total investment value, and the range of deal sizes have increased, while average investment size and post-investment company valuations decreased; funding was largely directed to pharmaceuticals/biotechnology, though historical maximum funding amounts for clinics/outpatient services, health information technology, and medical devices were achieved in 2021.

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Reduced levels of pNRF2 and NQO1 but not of BACH1 in the epidermis of patients with AD.

Koch et al. performed quantitative proteomics of epidermal samples from healthy volunteers and patients with atopic dermatitis to confirm differences in inflammation and defective keratinocyte differentiation and epidermal stratification in lesional and non-lesional skin from patients with atopic dermatitis and to reveal impairment of the NRF2-antioxidant pathway and reduced levels of mitochondrial proteins that function in metabolic pathways in lesional skin, suggesting targets for pharmaceutical interventions.

Proposed mechanism linking SPAG17 downregulation with SSc pathogenesis.

In studies aimed to identify transcripts that distinguish systemic sclerosis skin biopsies from healthy controls, Sapa et al. demonstrated reduced expression of the functionally poorly characterized SPAG17 gene in systemic sclerosis and that mice lacking Spag17 developed spontaneous skin fibrosis. Knockdown of SPAG17 in fibroblasts and microvascular endothelial cells was accompanied by spontaneous myofibroblast transformation. These studies identified SPAG17 as a regulator of myofibroblast differentiation and fibrotic responses, shedding light on systemic sclerosis pathogenesis.

 

Genetic characterization of the ARSI cell line.

Prochazkova-Carlotti et al. report successful expansion of cutaneous B lymphoma cells from a skin biopsy derived from an untreated woman with primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). Xenotransplantation of a tumor explant into an immune deficient mouse resulted in spread of tumor cells to several organs. After re-isolation of tumor cells from the mouse model, a clonal cell line was established that largely captures and retains the phenotypic and genomic features of the most common PCDLBCL-LT subtype. Both the patient-derived xenograft approach and the cell line will support drug screening efforts for treatment of this rare yet aggressive disease.

Methods and Techniqures in Skin Research
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Society for Investigative Dermatology (SID)

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

European Society for Dermatological Research (ESDR)

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.

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