Figure 2. Clinical presentation in humans of orthopoxvirus-based infections. (a) Replication-competent smallpox vaccine‒associated disseminated disease in a child with atopic dermatitis (eczema vaccinatum) and (b) a current case of monkeypox virus: a male patient aged 32 years with lesions affecting the genital area. Consent to publish images was provided by the parents of the child with eczema vaccinatum and from the subject who was infected with the monkeypox virus. The image of the child with (a) eczema vaccinatum was adapted from Vora et al., 2008 with permission of the Infectious Diseases Society of America. The image of the current case of (b) monkeypox virus was provided courtesy of Carina Borst, Department of Dermatology, Medical University of Vienna (Vienna, Austria).