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Journal of Investigative Dermatology

March 2023Volume 143Issue 3

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New & Noteworthy

Skin in the Game: An Analysis of Venture Capital Investment in Dermatology from 2002 to 2021

Aneesh Agarwal,Seth J. Orlow

Across >$9 billion invested in dermatology companies from 2002-2021, annual deal counts, total investment value, and the range of deal sizes have increased, while average investment size and post-investment company valuations decreased; funding was largely directed to pharmaceuticals/biotechnology, though historical maximum funding amounts for clinics/outpatient services, health information technology, and medical devices were achieved in 2021.

Articles in Press

• 
  Letters to the Editor

  Distinct HOX gene family DNA methylation profiles in histologically normal skin dependent on dermoscopic pattern of adjacent nevi

  Muse et al.

  Published online: March 20, 2023
• 
  Original Article

  Primary melanoma miRNAs trafficking induce lymphangiogenesis

  Leichner et al.

  Published online: March 17, 2023
• 
  Commentary

  CD38 Targeting Holds Potential for the Treatment of Aggressive Refractory Cutaneous T-Cell Lymphomas

  Pavlova et al.

  Published online: March 16, 2023
• 
  Original Article

  S100A9 drives the chronification of psoriasiform inflammation by inducing IL-23/type 3 immunity

  de Melo et al.

  Published online: March 13, 2023

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• Methods and Techniques for Skin Research

  Free

  Live Imaging with Genetically Encoded Physiologic Sensors and Optogenetic Tools

  Zaver et al.

https://www.youtube.com/embed/juG-Vyw8U5I

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Interested in writing an MTSR Article? Contact us at [email protected]

This Month's Highlights

https://www.youtube.com/embed/s5H5PcqTdHQ

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View Cover

• Original Article Gene Regulation

  Transcriptomic Heterogeneity of Skin Across Different Anatomic Sites

  Yan et al.

Yan et al. provide results of transcriptomic analysis based on RNA sequencing of 159 skin samples from head and neck, trunk and extremities, perineum, and palmoplantar regions, demonstrating that human skin exhibits transcriptomic heterogeneity that reflects variation in physiological and developmental processes at the different anatomic sites. The full results are available on an open website.

• Original Article InflammationOpen Access

  The p300/CBP Inhibitor A485 Normalizes Psoriatic Fibroblast Gene Expression In Vitro and Reduces Psoriasis-Like Skin Inflammation In Vivo

  Kim et al.

Kim et al. demonstrate that treatment with selective inhibitors of the histone acetyltransferase domain of p300/CBP reduced expression of several genes known to be upregulated in psoriatic fibroblasts. Treatment with this specific p300/CBP inhibitor reduced psoriasis-like skin inflammation in a murine model, suggesting not only that epigenetic modifications play a crucial role in psoriasis but also that inhibition of p300/CBP is a potential therapeutic strategy.

 

• Letters to the EditorOpen Access

  Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response during Wound Repair

  Sawaya et al.

The transcription factor SOX2 primes oral epithelium for rapid wound repair. Sawaya et al. report that SOX2 regulates K75 expression and that this keratin also becomes a component of the linker of nucleoskeleton and cytoskeleton (LINC) complex to mediate the SOX2 rapid healing response during wound repair.

Resources for Clinical Research in the JID

• 
  Methods and Techniques for Skin Research

  Noninferiority Randomized Controlled Trials

  Kim et al.

  Published in issue: July, 2022
• 
  Research Techniques Made Simple

  Open Archive

  Research Techniques Made Simple: An Introduction to Qualitative Research

  Bazen et al.

  Published in issue: February, 2021
• 
  Research Techniques Made Simple

  Open Archive

  Research Techniques Made Simple: Developing and Validating QOL Outcome Measures for Skin Diseases

  Braun et al.

  Published in issue: October, 2020
• 
  Research Techniques Made Simple

  Open Archive

  Research Techniques Made Simple: Latent Class Analysis

  Naldi et al.

  Published in issue: September, 2020

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About

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.

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5-Year Impact Factor

28 days

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• Top Social Media Articles
   

Most Read (Last 30 Days)

• 
  Original Article

  Open Access

  Endolysin inhibits skin colonization by patient-derived Staphylococcus aureus and malignant T cell activation in cutaneous T cell lymphoma

  Pallesen et al.

  Published online: March 6, 2023
• 
  Commentary

  Open Archive

  Recent Advances in Understanding Pemphigus and Bullous Pemphigoid

  Hammers et al.

  Published in issue: April, 2020
• 
  Original Article

  Open Access

  Mendelian Randomization Studies in Psoriasis and Psoriatic Arthritis: A Systematic Review

  Jin et al.

  Published online: February 21, 2023
• 
  Letter to the Editor

  Open Archive

  Genetic Basis of Male Pattern Baldness

  • Andrew C. Heath

  Nyholt et al.

  Published in issue: December, 2003
• 
  Methods and Techniques for Skin Research

  Live Imaging with Genetically Encoded Physiologic Sensors and Optogenetic Tools

  Zaver et al.

  Published in issue: March, 2023
• 
  Research Techniques Made Simple

  Open Archive

  Polymerase Chain Reaction

  Garibyan et al.

  Published in issue: March, 2013

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