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In the special section on itch in the January 2022 issue, 4 invited Reviews and a Commentary provide a complementary introduction into the exciting and rapidly advancing field of itch research. Stemming from cutting-edge research in neuroscience, immunology, and skin biology, these advancements, which are concisely described in these articles, are already impacting patient care.
Zhu et al. report that histone deacetylases 1/2 are essential for maintaining proliferation and survival of epidermal and basal cell carcinoma precursors via inhibition of p53 and p16. These findings suggest that the potential efficacy of inhibitors of these enzymes for treatment of skin cancers may depend on the status of p53 and p16 in the tumors. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article
Gharaee-Kermani et al. utilized the murine imiquimod model of human psoriasis to demonstrate that expression of IFN-κ regulates the initiation of psoriasiform inflammation, disease severity, neutrophil recruitment, and cytokine production. Targeting this type of interferon early in disease may control inflammation in psoriasis. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.
The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.
The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.
Dr. Janet A. Fairley, President of the Society for Investigative Dermatology leads an engaging conversation with Dr. Mark C. Udey, Editor-in-Chief of the Journal of Investigative Dermatology as well as Dr. Russell P. Hall III, Editor-in-Chief of our newest journal, JID Innovations.