The JID Connector offers online-only articles of direct clinical relevance for the dermatology and skin biology communities.

This Month's Highlights

Schwarz et al. report that the regulatory T cell impairment, inflammation, and altered cytokine profile that characterize psoriasis can be restored in a mouse model with topical treatment with the short-chain fatty acid sodium butyrate, which activates regulatory T cells, suggesting that such short-chain fatty acids offer therapeutic potential for this skin disease. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.
Rahman et al. describe a chemopreventive role for aspirin (acetylsalicylic acid [ASA]) in melanocytes and keratinocytes following UVB exposure, as ASA reduced UVB-induced inflammation and DNA damage and effectively delayed onset of squamous cell carcinoma following UVB exposure. See the accompanying commentary. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article .
Longmate et al. demonstrate that integrin α3β1 maintains tumor growth and regulates the keratinocyte secretome, including fibulin-2 and macrophage colony-stimulating factor 1, positioning integrin α3β1 as regulator of the skin tumor microenvironment via paracrine signaling between keratinocytes and stromal cells to yield a tumor-supportive skin tumor microenvironment.

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January 2021
Volume 141, Issue 1

COVID-19 and the JID

Call for Submissions on Autoimmunity

JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at [email protected] for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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19 November 2020:  Table of Contents December 2020 issue of the JID

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