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Journal of Investigative Dermatology

December 2021Volume 141Issue 12

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Articles in Press

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  Letters to the Editor

  Abdominal visceral adiposity is associated with coronary artery lipid-rich necrotic core partly mediated by bone marrow uptake of ¹⁸F-FDG PET / CT in psoriasis

  Manyak et al.

  Published online: November 28, 2021
• 
  Original Article

  Intravenous immunoglobulin regulates anti-desmoglein 3 IgG production in B220⁻ antibody-producing cells in mice with pemphigus vulgaris

  Kase et al.

  Published online: November 27, 2021
• 
  Review

  Immune Checkpoint Blockade and Skin Toxicity Pathogenesis

  Ma et al.

  Published online: November 26, 2021
• 
  Perspective

  Recalcitrant Warts, Epidermodysplasia Verruciformis, and the Tree-Man Syndrome: Phenotypic Spectrum of Cutaneous HPV Infections at the Intersection of Genetic Variability of Viral and Human Genomes

  Uitto et al.

  Published online: November 26, 2021

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This Month’s Highlights

• 

  Original Article Clinical Research: TherapeuticsOpen Access

  Safety, Tolerability, and Activity of ALXN1830 Targeting the Neonatal Fc Receptor in Chronic Pemphigus

  Werth et al.

  Published online: June 11, 2021

Werth et al. report clinical improvement and tolerability following treatment with ALXN1830, a humanized antibody that blocks interactions between the neonatal Fc receptor and IgG, among 8 patients with chronic pemphigus, a blistering disease caused by pathogenic IgG autoantibodies to desmosome components. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

• 

  Original Article Inflammation

  Antimicrobial Peptide LL-37 Drives Rosacea-Like Skin Inflammation in an NLRP3-Dependent Manner

  Yoon et al.

  Published online: March 17, 2021

Yoon et al. demonstrate that the antimicrobial peptide LL-37, which has been implicated in rosacea, induces NLRP3 inflammasome activation in this inflammatory skin disorder and that genetic or pharmacological inhibition of the inflammasome abrogates this inflammation, supporting exploration of this therapeutic target in rosacea. See the accompanying commentary.

• 

  Original Article Melanocytes/Melanoma

  The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma

  Wang et al.

  Published online: May 25, 2021

Wang et al describe a regulatory mechanism involving the XBP1‒MARCH5‒MFN2 axis, whereby mitochondrial fission and mitophagy are involved in the resistance to endoplasmic reticulum stress in melanoma cells. These findings may inform clinical advances as melanoma cells are often recalcitrant to endoplasmic reticulum stress, leading to tumor progression and therapeutic resistance. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

About

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.

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5-Year Impact Factor

28 days

Average to First Decision

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Most Read (Last 30 Days)

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  Original Article

  Open Access

  Nicotinamide Prevents UVB- and Oxidative Stress-Induced Photoaging in Human Primary Keratinocytes

  Tan et al.

  Published online: November 2, 2021
• Miscellaneous

  Subscription Information

  Published in issue: December 2021
• Contents list

  Table of Contents

  Published in issue: December 2021
• Editorial Board

  Editorial Board

  Published in issue: December 2021
• 
  Review

  From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

  Arkin et al.

  Published online: July 14, 2021
• 
  Commentary

  Impaired Autophagy in Psoriasis and Atopic Dermatitis: A New Therapeutic Target?

  Hailfinger et al.

  Published online: September 22, 2021

Most Cited (Previous 3 Years)

• Open Access

  Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm

  • Han et al.

  Journal of Investigative Dermatology, Vol.138, No.7, p1529-1538

  July 2018
• Open Access

  Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

  • Philippeos et al.

  Journal of Investigative Dermatology, Vol.138, No.4, p811-825

  April 2018
• Open Access

  The Genetics of Chronic Itch: Gene Expression in the Skin of Patients with Atopic Dermatitis and Psoriasis with Severe Itch

  • Nattkemper et al.

  Journal of Investigative Dermatology, Vol.138, No.6, p1311-1317

  June 2018
• Open Access

  Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3

  • Regazzetti et al.

  Journal of Investigative Dermatology, Vol.138, No.1, p171-178

  January 2018
• Open Access

  Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

  • Slominski et al.

  Journal of Investigative Dermatology, Vol.138, No.3, p490-499

  March 2018

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