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ORIGINAL ARTICLE

Induction of regulatory T cells and correction of cytokine dysbalance by short chain fatty acids — Implications for the therapy of psoriasis FREE

Schwarz et al. report that the regulatory T cell impairment, inflammation, and altered cytokine profile that characterize psoriasis can be restored in a mouse model with topical treatment with the short-chain fatty acid sodium butyrate, which activates regulatory T cells, suggesting that such short-chain fatty acids offer therapeutic potential for this skin disease. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.

ORIGINAL ARTICLE

Aspirin protects melanocytes and keratinocytes against UVB-induced DNA damage in vivo FREE

Rahman et al. describe a chemopreventive role for aspirin (acetylsalicylic acid [ASA]) in melanocytes and keratinocytes following UVB exposure, as ASA reduced UVB-induced inflammation and DNA damage and effectively delayed onset of squamous cell carcinoma following UVB exposure. See the accompanying commentary. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article .

ORIGINAL ARTICLE

Integrin α3β1 on tumor keratinocytes is essential to maintain tumor growth and promotes a tumor-supportive keratinocyte secretome FREE

Longmate et al. demonstrate that integrin α3β1 maintains tumor growth and regulates the keratinocyte secretome, including fibulin-2 and macrophage colony-stimulating factor 1, positioning integrin α3β1 as regulator of the skin tumor microenvironment via paracrine signaling between keratinocytes and stromal cells to yield a tumor-supportive skin tumor microenvironment.

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Summary of Alopecia Areata Research Workshop and Future Research Directions

Lowell A. Goldsmith

Journal of Investigative Dermatology, Vol. 96, Issue 5

Published in issue: May 1991

Open Archive

The DEBR rat model for alopecia areata

Roy F. Oliver, Colin A.B. Jahoda, Kenneth A. Horne, Hilary J. Michie, Terry Poulton, Brian E. Johnson

Journal of Investigative Dermatology, Vol. 96, Issue 5

Published in issue: May 1991

Open Archive

Inherited mouse mutations: Models for the study of alopecia

John P. Sundberg, Leonard D. Shultz

Journal of Investigative Dermatology, Vol. 96, Issue 5

Published in issue: May 1991

Open Archive

Autoreactive cells in alopecia areata

Maria K. Hordinsky, Richard S. Kalish

Journal of Investigative Dermatology, Vol. 96, Issue 5

Published in issue: May 1991

Open Archive

Aberrant intercellular adhesion molecule-1 (ICAM-1) expression by hair-follicle epithelial cells and endothelial leukocyte adhesion molecule-1 (ELAM-1) by vascular cells are important adhesion-molecule alterations in alopecia areata

Brian J. Nickoloff, Christopher E.M. Griffiths

Journal of Investigative Dermatology, Vol. 96, Issue 5

Published in issue: May 1991

Open Archive

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Human dermal fibroblast subpopulations are conserved across single-cell RNA sequencing studies

Alex M. Ascensión, Sandra Fuertes-Álvarez, Olga Ibañez-Solé, Ander Izeta, Marcos J. Araúzo-Bravo

DOI: https://doi.org/10.1016/j.jid.2020.11.028

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Open Access

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Induction of Regulatory T Cells and Correction of Cytokine Disbalance by Short-Chain Fatty Acids: Implications for Psoriasis Therapy

Agatha Schwarz, Rebecca Philippsen, Thomas Schwarz

DOI: https://doi.org/10.1016/j.jid.2020.04.031

Journal of Investigative Dermatology, Vol. 141, Issue 1

Abstract Image

CYP1A1 enzymatic activity influences skin inflammation via regulation of the AHR pathway

Mariela Kyoreva, Ying Li, Mariyah Hoosenally, Jonathan Hardman-Smart, Kirsten Morrison, Isabella Tosi, Mauro Tolaini, Guillermo Barinaga, Brigitta Stockinger, Ulrich Mrowietz, Frank O. Nestle, Catherine Smith, Jonathan N. Barker, Paola Di Meglio

DOI: https://doi.org/10.1016/j.jid.2020.11.024

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Open Access

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Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo

Hafeez Rahman, Dileep Kumar, Tong Liu, Nwanneka Okwundu, David Lum, Scott R. Florell, Christin E. Burd, Kenneth M. Boucher, Matthew W. VanBrocklin, Douglas Grossman

DOI: https://doi.org/10.1016/j.jid.2020.06.003

Journal of Investigative Dermatology, Vol. 141, Issue 1

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Research Techniques Made Simple: Analysis of Autophagy in the Skin

David Hill, Ioana Cosgarea, Nick Reynolds, Penny Lovat, Jane Armstrong

DOI: https://doi.org/10.1016/j.jid.2020.10.004

Journal of Investigative Dermatology, Vol. 141, Issue 1

Cover image volume 141, Issue 1

January 2021

Volume 141, Issue 1

January 2021
Volume 141, Issue 1

JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at [email protected] for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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