New & Noteworthy

K08 versus K23 grants awarded from 2012 to 2021 across different specialties supported by NIAMS.
  • Distribution of Early Career Research Funding by Specialty from the National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Biomedical research includes basic research on mechanisms underlying the function of organisms and clinical or patient-oriented research to produce knowledge for preventing and treating illness (National Research Council (US) Committee for Monitoring the Nation’s Changing Needs for Biomedical, Behavioral, and Clinical Personnel, 2005). In response to emerging concerns decades ago about the relative lack of National Institutes of Health (NIH) funding for clinical research (Nathan and Wilson, 2003; Williams et al., 1997; Wyngaarden, 1979), efforts were made to support clinical investigators, including initiating the K23 award for career development in clinical research (Teo, 2009; Zerhouni, 2003).
Join Us for the First International Societies for Investigative Dermatology Meeting Tokyo 2023
  • 2023 Marks the First International Societies for Investigative Dermatology Meeting in Tokyo

    In May of 2013, the Japanese Society for Investigative Dermatology (JSID), the European Society for Dermatological Research (ESDR), and the Society for Investigative Dermatology (SID) signed a memorandum of understanding to establish a new organization, the International Societies for Investigative Dermatology (ISID) (Amagai et al., 2014). The goal of the ISID was to unite all societies worldwide that are focused on investigative dermatology and cutaneous biology. It was our collective vision that such an organization would enhance scientific collaboration and jointly sponsor an abstract-driven, peer-reviewed meeting every 5 years.

Articles in Press

Methods and Techniqures in Skin Research
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This Month's Highlights

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3D Reconstruction of Desmoglein-1 in Adult Human Epidermis
Whole-mount imaging of adult human epidermis stained for the desmosomal cadherin, Desmoglein-1 (Dsg1) were imaged using Nikon A1R+ confocal. 3D reconstruction using NIS Elements was implemented with Volume Viewer’s Depth Coded Alpha Blending (rainbow contrast look up table). The basal/proliferation layer is blue and teal, spinous/early differentiation layer is green and yellow, and granular/late differentiated layer is red and pink. Video courtesy of Marihan Hegazy and Jennifer Koetsier, Department of Pathology, Northwestern University.

Galectin-12 is associated with lipid droplets in human SZ95 sebocytes.

Sebaceous glands regulate skin homeostasis and maintain barrier function via sebum production by sebocytes. In studies using galectin-12-deficient mice, Tsao et al. demonstrate that galectin-12, which is expressed adipocytes and sebocytes, plays a role in sebocyte differentiation and sebum lipid metabolism via activation of PPARγ transcriptional activity.

The schematic model of fibrosis formation by skin or lung fibroblasts through the TGF-β/SMAD and the SOX11/periostin pathway.

TGF-β is critical for fibrosis via upregulation of collagen and other extracellular matrix proteins; promotion of fibroblast proliferation, differentiation, migration, and adhesion; and induction of cytokine secretion. Nanri et al. report that SOX11 and periostin comprise a positive feedback loop in fibroblasts to upregulate TGF-β signaling and lead to skin fibrosis. These findings may have clinical implications for fibrosis underlying systemic sclerosis disease.


rFGF4 accelerates wound re-epithelialization in mice.

Sun et al. find that paracrine FGF4, which is upregulated at wound edges, enhances p38 MAPK-GSK3b-mediated stabilization of the epithelial-to-mesenchymal transition transcription factor Slug. This stabilization triggers the epithelial-to-mesenchymal transition and promotes keratinocyte proliferation and migration, leading to wound re-epithelialization, which is crucial for wound closure.

Resources for Clinical Research in the JID


Society for Investigative Dermatology (SID)

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

European Society for Dermatological Research (ESDR)

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.



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