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Journal of Investigative Dermatology

February 2022Volume 142Issue 2

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Articles in Press

• 
  Original Article

  TNFR2 depletion reduces psoriatic inflammation in mice via downregulating specific dendritic cell populations in lymph nodes and inhibiting IL-23/IL-17 pathways.

  Chandrasekharan et al.

  Published online: January 25, 2022
• 
  Original Article

  KLHL24-mediated hair follicle stem cells structural disruption causes alopecia

  Cui et al.

  Published online: January 20, 2022
• 
  Original Article

  TSLP impairs epidermal barrier integrity by stimulating the formation of nuclear IL-33/phosphorylated STAT3 complex in human keratinocytes

  Dai et al.

  Published online: January 19, 2022
• 
  Letters to the Editor

  A murine Kitl allele regulates skin mast cell density across 58 collaborative mouse cross strains

  Walker et al.

  Published online: January 18, 2022

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This Month's Highlights

image credit:  RyanKing999 on istockphoto.com

In the special section on itch in the January 2022 issue, 4 invited Reviews and a Commentary provide a complementary introduction into the exciting and rapidly advancing field of itch research. Stemming from cutting-edge research in neuroscience, immunology, and skin biology, these advancements, which are concisely described in these articles, are already impacting patient care.

• Original Article Cell BiologyOpen Access

  HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53

  Zhu et al.

Zhu et al. report that histone deacetylases 1/2 are essential for maintaining proliferation and survival of epidermal and basal cell carcinoma precursors via inhibition of p53 and p16. These findings suggest that the potential efficacy of inhibitors of these enzymes for treatment of skin cancers may depend on the status of p53 and p16 in the tumors. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article

• Original Article Inflammation

  IFN-κ Is a Rheostat for Development of Psoriasiform Inflammation

  Gharaee-Kermani et al.

Gharaee-Kermani et al. utilized the murine imiquimod model of human psoriasis to demonstrate that expression of IFN-κ regulates the initiation of psoriasiform inflammation, disease severity, neutrophil recruitment, and cytokine production. Targeting this type of interferon early in disease may control inflammation in psoriasis. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

About

The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.

The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.

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5-Year Impact Factor

28 days

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Meet the Editors of the JID Family of Journals

Dr. Janet A. Fairley, President of the Society for Investigative Dermatology leads an engaging conversation with Dr. Mark C. Udey, Editor-in-Chief of the Journal of Investigative Dermatology as well as Dr. Russell P. Hall III, Editor-in-Chief of our newest journal, JID Innovations.

Most Read (Last 30 Days)

• 
  Original Article

  Open Access

  Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma

  Liyanage et al.

  Published online: November 19, 2021
• Miscellaneous

  Subscription Information

  Published in issue: February 2022
• 
  Original Article

  Open Access

  C5aR2 deficiency ameliorates inflammation in murine epidermolysis bullosa acquisita by regulating FcγRIIb expression on neutrophils

  Seiler et al.

  Published online: January 7, 2022
• Original Article Clinical Research

  Open Access

  Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population

  Chiesa Fuxench et al.

  Published online: October 30, 2018
• 
  Spotlight on Itch

  Interactions of the Neuro‒Immune‒Stromal Triad in Itch

  Tseng et al.

  Published online: October 15, 2021
• 
  Original Article Cell Biology

  Open Access

  HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53

  Zhu et al.

  Published online: July 17, 2021

Most Cited (Previous 3 Years)

• Open Access

  Atopic Dermatitis Is an IL-13–Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis

  • Tsoi et al.

  Journal of Investigative Dermatology, Vol.139, No.7, p1480-1489

  July 2019
• Open Access

  Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population

  • Chiesa Fuxench et al.

  Journal of Investigative Dermatology, Vol.139, No.3, p583-590

  March 2019
• Open Access

  Impact of Secukinumab on Endothelial Dysfunction and Other Cardiovascular Disease Parameters in Psoriasis Patients over 52 Weeks

  • von Stebut et al.

  Journal of Investigative Dermatology, Vol.139, No.5, p1054-1062

  May 2019
• Open Access

  The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction

  • Witte-Händel et al.

  Journal of Investigative Dermatology, Vol.139, No.6, p1294-1305

  June 2019
• Open Access

  A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin

  • Gallant-Behm et al.

  Journal of Investigative Dermatology, Vol.139, No.5, p1073-1081

  May 2019

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