Home Page: Journal of Investigative Dermatology

ORIGINAL ARTICLE

TERT, BRAF, and NRAS mutational heterogeneity between paired primary and metastatic melanoma tumors FREE

Using multiple molecular sequencing methods, Chang et al. found heterogeneity in the presence of BRAF^V600, NRAS^Q61, TERT^124C>T, and TERT^146C>T mutations in paired primary and metastatic tumors or multiple metastatic tumors from 18 of 99 (18%) patients with melanoma. These results suggest that differing mutational profiles occur in primary melanomas from the same individual and that this information is integral to treatment response and disease outcomes. .

ORIGINAL ARTICLE

Identification of a human skin commensal bacterium that selectively kills Cutibacterium acnes FREE

O'Neill et al. describe antimicrobial peptides that are secreted by the skin-resident commensal Staphylococcus capitis E12 and selectively inhibit growth of the acne vulgaris pathogen Cutiebacterium acnes, highlighting the potential for identification of novel antibacterial agents for treatment of skin diseases from the skin microbiome. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.

ORIGINAL ARTICLE

PAR2 mediates itch via TRPV3 signaling in keratinocytes FREE

Zhao et al. report that in keratinocytes, TRPV3 and PAR2, which are upregulated in skin of patients with atopic dermatitis, function together as part of a signaling cascade to convey itch, indicating that targeting of either of these components may provide a potential antipruritic therapy for atopic dermatitis. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

View Current Issue

CLINICAL RELEVANCE OF POLYMORPHONUCLEAR MYELOID-DERIVED SUPPRESSOR CELLS (PMN-MDSC) IN AUTOIMMUNE BLISTERING DISORDERS PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID

Ayse Oktem, Utku Horzum, Pelin Ertop, Nihal Kundakci, Bengu Nisa Akay, Basak Yalcin, Gunes Esendagli

DOI: https://doi.org/10.1016/j.jid.2020.07.015

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 9, 2020

The Genetic Basis of Vitiligo

Richard A. Spritz, Stephanie A. Santorico

DOI: https://doi.org/10.1016/j.jid.2020.06.004

Publication stage: In Press Corrected Proof

Journal of Investigative Dermatology

Published online: August 8, 2020

The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

Karthic Swaminathan, Andrew Campbell, Vassilis Papalazarou, Farah Jaber-Hijazi, Colin Nixon, Ewan McGhee, Douglas Strathdee, Owen J. Sansom, Laura M. Machesky

DOI: https://doi.org/10.1016/j.jid.2020.06.029

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 7, 2020

MRGPRX2 Activation Causes Increased Skin Reactivity in Chronic Spontaneous Urticaria Patients

Maria Shtessel, Nathachit Limjunyawong, Eric T. Oliver, Kristin Chichester, Li Gao, Xinzhong Dong, Sarbjit S. Saini

DOI: https://doi.org/10.1016/j.jid.2020.06.030

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 6, 2020

Identification of a mosaic activating mutation in GNA11 in atypical Sturge-Weber Syndrome

Jeremy Thorpe, Laurence P. Frelin, Meghan McCann, Carlos A. Pardo, Bernard A. Cohen, Anne M. Comi, Jonathan Pevsner

DOI: https://doi.org/10.1016/j.jid.2020.03.978

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 6, 2020

View More Articles in Press

Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

Sorel Fitz-Gibbon, Shuta Tomida, Bor-Han Chiu, Lin Nguyen, Christine Du, Minghsun Liu, David Elashoff, Marie C. Erfe, Anya Loncaric, Jenny Kim, Robert L. Modlin, Jeff F. Miller, Erica Sodergren, Noah Craft, George M. Weinstock, Huiying Li

DOI: https://doi.org/10.1038/jid.2013.21

Journal of Investigative Dermatology, Vol. 133, Issue 9

Open Archive

Author Index

DOI: https://doi.org/10.1016/j.jid.2018.03.1494

Journal of Investigative Dermatology, Vol. 138, Issue 5

Open Archive

Research Techniques Made Simple: Optical Clearing and Three-Dimensional Volumetric Imaging of Skin Biopsies

Yingrou Tan, Carolyn Pei Lyn Chiam, Yuning Zhang, Hong Liang Tey, Lai Guan Ng

DOI: https://doi.org/10.1016/j.jid.2020.04.014

Journal of Investigative Dermatology, Vol. 140, Issue 7

773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

I. Piccini, K. Bakkar, C. Collin-Djangoné, J. Gherardini, R. Paus, M. Bertolini

DOI: https://doi.org/10.1016/j.jid.2020.03.787

Journal of Investigative Dermatology, Vol. 140, Issue 7

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

Marika Catapano, Marta Vergnano, Marco Romano, Satveer K. Mahil, Siew-Eng Choon, A. David Burden, Helen S. Young, Ian M. Carr, Helen J. Lachmann, Giovanna Lombardi, Catherine H. Smith, Francesca D. Ciccarelli, Jonathan N. Barker, Francesca Capon

DOI: https://doi.org/10.1016/j.jid.2019.08.444

Journal of Investigative Dermatology, Vol. 140, Issue 4

Open Access

August 2020

Volume 140, Issue 8

August 2020
Volume 140, Issue 8

JID invites submission of reports in the field of aging for a Special Issue on Aging. Areas of interest include senescence, regeneration, life span, DNA damage and repair, telomeres, calorie restriction, longevity, mitotic ageing rate, and stem cells. Manuscript deadline: September 1, 2020. Contact the Editor at JIDEditor@sidnet.org for submission details. For additional details, please see the full announcement.

SkinPods
Video

This Month in the JID Connector

SnapshotDx Quiz: August 2020

Cells to Surgery Quiz: August 2020

Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research

This Month's Highlights

SID 2020 Meeting Abstract Supplement

Publishing Partners

CLINICAL RELEVANCE OF POLYMORPHONUCLEAR MYELOID-DERIVED SUPPRESSOR CELLS (PMN-MDSC) IN AUTOIMMUNE BLISTERING DISORDERS PEMPHIGUS VULGARIS AND BULLOUS PEMPHIGOID

The Genetic Basis of Vitiligo

The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

MRGPRX2 Activation Causes Increased Skin Reactivity in Chronic Spontaneous Urticaria Patients

Identification of a mosaic activating mutation in GNA11 in atypical Sturge-Weber Syndrome

Most Downloaded JID Articles Published Since 2014

Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

Author Index

Research Techniques Made Simple: Optical Clearing and Three-Dimensional Volumetric Imaging of Skin Biopsies

773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab

Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes

Current Issue

COVID-19 and the JID

Call for Submissions on Aging

Journal Metrics

List of Issues

JID Author Corner

Social Media