Home Page: Journal of Investigative Dermatology

ORIGINAL ARTICLE

Rituximab and Corticosteroid Effect on Desmoglein-Specific B Cells and Desmoglein-Specific T Follicular Helper Cells in Pemphigus FREE

Maho-Vaillant et al. demonstrate that long-lasting efficacy of rituximab treatment in pemphigus patients results from long-lasting depletion of desmoglein-specific B cells in combination with altered maturation and class-switching of these cells. These changes likely stem from diminished desmoglein-specific T follicular helper cells, which are associated with the anti-desmoglein 3 response in patients with pemphigus. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

ORIGINAL ARTICLE

The Polyamine Regulator AMD1 Upregulates Spermine Levels to Drive Epidermal Differentiation FREE

Rahim et al. describe regulation of keratinocyte differentiation by AMD1, a regulator of polyamine levels that are altered in skin disorders and skin cancer. AMD1 protein, which is upregulated during keratinocyte differentiation, alters putrescine and spermine ratios, leading to transcription factor and signaling protein expression changes to drive cellular changes. These findings suggest that modulation of polyamines may be useful in the treatment of hyperproliferative skin disorders. See the accompanying commentary. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.

LETTER TO THE EDITOR

Adenosine Triphosphate Released by Candida albicans Is Associated with Reduced Skin Infectivity FREE

Zhang et al. find that Candida albicans, which grows as both a commensal and a pathogen at barrier sites in humans, releases variable amounts of extracellular ATP and that strains that secrete lower levels are associated with increased infection. These findings suggest that eATP release by C. albicans may induce inflammasome activation and promote host defense against the organism. See the accompanying commentary.

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Genomic progression of precancerous actinic keratosis to squamous cell carcinoma

Yoon-Seob Kim, Sun Shin, Seung-Hyun Jung, Young Min Park, Gyeong Sin Park, Sug Hyung Lee, Yeun-Jun Chung

DOI: https://doi.org/10.1016/j.jid.2021.07.172

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: September 1, 2021

Open Access

Specific β-defensins stimulate pruritus through activation of sensory neurons

Pang-Yen Tseng, Mark A. Hoon

DOI: https://doi.org/10.1016/j.jid.2021.07.178

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: September 1, 2021

Merkel cell polyomavirus-negative -Merkel cell carcinoma originating from in situ squamous cell carcinoma: a keratinocytic tumor with neuroendocrine differentiation

Thibault Kervarrec, Silke Appenzeller, Mahtab Samimi, Bhavishya Sarma, Eva-Maria Sarosi, Patricia Berthon, Yannick Le Corre, Ewa Hainaut-Wierzbicka, Astrid Blom, Nathalie Benethon, Guido Bens, Charline Nardin, Francois Aubin, Monica Dinulescu, Marie-Laure Jullie, Ágnes Pekár-Lukacs, Eduardo Calonje, Soumanth Thanguturi, Anne Tallet, Marion Wobser, Antoine Touzé, Serge Guyétant, Roland Houben, David Schrama

DOI: https://doi.org/10.1016/j.jid.2021.07.175

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 31, 2021

Immunocompromised patients with therapy-refractory chronic skin diseases show reactivation of latent EBV and CMV infection

Philipp Speth, Manja Jargosch, Peter Seiringer, Kristina Schwamborn, Tanja Bauer, Cora Scheerer, Ulrike Protzer, Carsten Schmidt-Weber, Tilo Biedermann, Stefanie Eyerich, Natalie Garzorz-Stark

DOI: https://doi.org/10.1016/j.jid.2021.07.171

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: August 31, 2021

The Skin's Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation

Lars Norlén, Magnus Lundborg, Christian Wennberg, Ali Narangifard, Bertil Daneholt

DOI: https://doi.org/10.1016/j.jid.2021.06.037

Publication stage: In Press Corrected Proof

Journal of Investigative Dermatology

Published online: August 31, 2021

Open Access

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Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase–2 Activation in Copper/Zinc Superoxide Dismutase–Deficient Mice

Juewon Kim, Toshihiko Toda, Kenji Watanabe, Shuichi Shibuya, Yusuke Ozawa, Naotaka Izuo, Siyoung Cho, Dae Bang Seo, Koutaro Yokote, Takahiko Shimizu

DOI: https://doi.org/10.1016/j.jid.2018.10.012

Journal of Investigative Dermatology, Vol. 139, Issue 3

Open Archive

New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine

Di Yan, Johann E. Gudjonsson, Stephanie Le, Emanual Maverakis, Olesya Plazyo, Christopher Ritchlin, Jose U. Scher, Roopesh Singh, Nicole L. Ward, Stacie Bell, Wilson Liao

DOI: https://doi.org/10.1016/j.jid.2021.02.764

Journal of Investigative Dermatology, Vol. 141, Issue 9

Open Access

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Daphne S. Bakker, Maria M. van der Wal, Lukas E.M. Heeb, Barbara Giovannone, Mindy Asamoah, Eveline M. Delemarre, Julia Drylewicz, Stefan Nierkens, Onur Boyman, Marjolein S. de Bruin-Weller, Judith L. Thijs, Femke van Wijk

DOI: https://doi.org/10.1016/j.jid.2021.01.022

Journal of Investigative Dermatology, Vol. 141, Issue 8

Open Access

Assessing the Risk and Outcome of COVID-19 in Patients with Psoriasis or Psoriatic Arthritis on Biologic Treatment: A Critical Appraisal of the Quality of the Published Evidence

Stefano Piaserico, Paolo Gisondi, Simone Cazzaniga, Sara Di Leo, Luigi Naldi

DOI: https://doi.org/10.1016/j.jid.2021.04.036

Publication stage: In Press Corrected Proof

Journal of Investigative Dermatology

Deciphering mesenchymal drivers of human Dupuytren’s disease at single-cell level.

Ross Dobie, Chris C. West, Beth EP. Henderson, John R. Wilson-Kanamori, Dyana Markose, Laura J. Kitto, Jordan R. Portman, Mariana Beltran, Sadaf Sohrabi, Ahsan R. Akram, Prakash Ramachandran, Li Yenn Yong, Dominique Davidson, Neil C. Henderson

DOI: https://doi.org/10.1016/j.jid.2021.05.030

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Open Access

September 2021

Volume 141, Issue 9

September 2021
Volume 141, Issue 9

Dr. Janet A. Fairley, President of the Society for Investigative Dermatology leads an engaging conversation with Dr. Mark C. Udey, Editor-in-Chief of the Journal of Investigative Dermatology as well as Dr. Russell P. Hall III, Editor-in-Chief of our newest journal, JID Innovations.

JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at [email protected] for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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Genomic progression of precancerous actinic keratosis to squamous cell carcinoma

Specific β-defensins stimulate pruritus through activation of sensory neurons

Merkel cell polyomavirus-negative -Merkel cell carcinoma originating from in situ squamous cell carcinoma: a keratinocytic tumor with neuroendocrine differentiation

Immunocompromised patients with therapy-refractory chronic skin diseases show reactivation of latent EBV and CMV infection

The Skin's Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation

Most Downloaded JID Articles Published Since 2014

Syringaresinol Reverses Age-Related Skin Atrophy by Suppressing FoxO3a-Mediated Matrix Metalloproteinase–2 Activation in Copper/Zinc Superoxide Dismutase–Deficient Mice

New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Assessing the Risk and Outcome of COVID-19 in Patients with Psoriasis or Psoriatic Arthritis on Biologic Treatment: A Critical Appraisal of the Quality of the Published Evidence

Deciphering mesenchymal drivers of human Dupuytren’s disease at single-cell level.

2020 Cited articles

The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab

Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes

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