Home Page: Journal of Investigative Dermatology

ORIGINAL ARTICLE

Integrin a3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis FREE

Ramovs et al. demonstrate that integrin a3β1 activates multiple protumorigenic signaling pathways (FAK/Src, Akt, and STAT3) in transformed keratinocytes during the initiation and outgrowth of tumorigenesis. Although these functions are independent of laminin binding, integrin a3β1 requires binding of the tetraspanin CD151 to promote cell-cell adhesion and promote tumorigenesis, highlighting a role for these players in the early stages of skin cancer. See the accompanying commentary. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.

ORIGINAL ARTICLE

Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry FREE

Using data from a cohort of 2,500 twins and a genome-wide association meta-analysis of more than 260,000 subjects of European ancestry, Sanna et al. find that sun-seeking behavior is heritable and identify five significant loci associated with addiction, behavioral and personality traits, cognitive function, and educational attainment. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.

ORIGINAL ARTICLE

Neutrophils Enhance Cutaneous Vascular Dilation and Permeability to Aggravate Psoriasis by Releasing Matrix Metallopeptidase 9 FREE

Chen et al. report that infiltrating neutrophils are activated upon interaction with vascular endothelial cells to promote vascular remodeling, vasodilation, and vascular barrier permeability via secretion of matrix metalloproteinase 9 (MMP-9). In a mouse model of psoriasis, inhibition of MMP-9 attenuated epidermal hyperplasia, inflammation, and vascular remodeling, supporting therapeutic targeting of this proteinase in psoriasis. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

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Melanoma differentiation trajectories determine sensitivity towards pre-existing CD8⁺ tumor-infiltrating lymphocytes

Franziska Noelle Harbers, Beatrice Thier, Simone Stupia, Si Zhu, Marion Schwamborn, Vicky Peller, Heike Chauvistré, Pietro Crivello, Katharina Fleischhauer, Alexander Roesch, Antje Sucker, Dirk Schadendorf, Yong Chen, Annette Paschen, Fang Zhao

DOI: https://doi.org/10.1016/j.jid.2021.03.013

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: March 29, 2021

ATP released by Candida albicans is associated with reduced skin infectivity

Shiqun Zhang, Tara N. Edwards, Selene Mogavero, Bernhard Hube, Judith Berman, Marie-Elisabeth Bougnoux, Christophe D'Enfert, Daniel H. Kaplan

DOI: https://doi.org/10.1016/j.jid.2021.03.010

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: March 27, 2021

A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma

Abdullah Al Emran, Hsin-Yi Tseng, Dilini Gunatilake, Stuart J. Cook, Farzana Ahmed, Shudong Wang, Peter Hersey, Stuart J. Gallagher, Jessamy C. Tiffen

DOI: https://doi.org/10.1016/j.jid.2020.12.038

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: March 25, 2021

Long-term effects of sirolimus on human skin TSC2-null fibroblast-like cells

Xiong Cai, Qingyuan Fan, Gi Soo Kang, Kelsey Grolig, Xiaoyan Shen, Eric M. Billings, Gustavo Pacheco-Rodriguez, Thomas N. Darling, Joel Moss

DOI: https://doi.org/10.1016/j.jid.2021.02.754

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: March 24, 2021

Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenance

Andrei Mardaryev, Max van Lessen, Majid Alam, Francisco Jimenez Acosta, Tamás Bíró, Ralf Paus

DOI: https://doi.org/10.1016/j.jid.2021.02.747

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Published online: March 24, 2021

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Multi-omics analysis and systems biology integration identifies the roles of IL-9 in keratinocyte metabolic reprogramming

Soumitra Marathe, Bhavuk Dhamija, Sushant Kumar, Nikita Jain, Sarbari Ghosh, Jai Prakash, Sumana Srinivasan, Sreya Das, Abhijeet Sawant, Saloni Desai, Farhat Khan, Abigail Syiemlieh, Manohar Munde, Chitra Nayak, Mayuri Gandhi, Ashutosh Kumar, Sanjeeva Srivastava, K.V. Venkatesh, Steven R. Barthel, Rahul Purwar

DOI: https://doi.org/10.1016/j.jid.2021.02.013

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Principles of the Molecular and Cellular Mechanisms of Aging

Paulo F.L. da Silva, Björn Schumacher

DOI: https://doi.org/10.1016/j.jid.2020.11.018

Journal of Investigative Dermatology, Vol. 141, Issue 4

The Aging Skin: From Basic Mechanisms to Clinical Applications

Björn Schumacher, Thomas M. Krieg

DOI: https://doi.org/10.1016/j.jid.2020.12.002

Journal of Investigative Dermatology, Vol. 141, Issue 4

MTH1 inhibitors for the treatment of psoriasis

Cecilia Bivik Eding, Ines Köhler, Deepti Verma, Florence Sjögren, Claudia Bamberg, Stella Karsten, Therese Pham, Martin Scobie, Thomas Helleday, Ulrika Warpman Berglund, Charlotta Enerbäck

DOI: https://doi.org/10.1016/j.jid.2021.01.026

Publication stage: In Press Journal Pre-Proof

Journal of Investigative Dermatology

Open Access

Polymerase Chain Reaction

Lilit Garibyan, Nidhi Avashia

DOI: https://doi.org/10.1038/jid.2013.1

Journal of Investigative Dermatology, Vol. 133, Issue 3

Open Archive

April 2021

Volume 141, Issue 4

April 2021
Volume 141, Issue 4

JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at [email protected] for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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Melanoma differentiation trajectories determine sensitivity towards pre-existing CD8⁺ tumor-infiltrating lymphocytes

ATP released by Candida albicans is associated with reduced skin infectivity

A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma

Long-term effects of sirolimus on human skin TSC2-null fibroblast-like cells

Hair follicle chemosensation: TRPM5 signalling is required for anagen maintenance

Most Downloaded JID Articles Published Since 2014

Multi-omics analysis and systems biology integration identifies the roles of IL-9 in keratinocyte metabolic reprogramming

Principles of the Molecular and Cellular Mechanisms of Aging

The Aging Skin: From Basic Mechanisms to Clinical Applications

MTH1 inhibitors for the treatment of psoriasis

Polymerase Chain Reaction

2020 Cited articles

The spectrum of manifestations in desmoplakin gene (DSP) spectrin repeat 6 domain mutations: Immunophenotyping and response to ustekinumab

Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes

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