The JID Connector offers online-only articles of direct clinical relevance for the dermatology and skin biology communities.


This Month's Highlights

Ramovs et al. demonstrate that integrin a3β1 activates multiple protumorigenic signaling pathways (FAK/Src, Akt, and STAT3) in transformed keratinocytes during the initiation and outgrowth of tumorigenesis. Although these functions are independent of laminin binding, integrin a3β1 requires binding of the tetraspanin CD151 to promote cell-cell adhesion and promote tumorigenesis, highlighting a role for these players in the early stages of skin cancer. See the accompanying commentary. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.
Using data from a cohort of 2,500 twins and a genome-wide association meta-analysis of more than 260,000 subjects of European ancestry, Sanna et al. find that sun-seeking behavior is heritable and identify five significant loci associated with addiction, behavioral and personality traits, cognitive function, and educational attainment. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.
Chen et al. report that infiltrating neutrophils are activated upon interaction with vascular endothelial cells to promote vascular remodeling, vasodilation, and vascular barrier permeability via secretion of matrix metalloproteinase 9 (MMP-9). In a mouse model of psoriasis, inhibition of MMP-9 attenuated epidermal hyperplasia, inflammation, and vascular remodeling, supporting therapeutic targeting of this proteinase in psoriasis. See the accompanying commentary. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article.

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April 2021
Volume 141, Issue 4

April 2021 Supplement Issue

COVID-19 and the JID

Call for Submissions on Autoimmunity

JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at [email protected] for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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19 February 2021:  Table of Contents March 2021 issue of the JID

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