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Across >$9 billion invested in dermatology companies from 2002-2021, annual deal counts, total investment value, and the range of deal sizes have increased, while average investment size and post-investment company valuations decreased; funding was largely directed to pharmaceuticals/biotechnology, though historical maximum funding amounts for clinics/outpatient services, health information technology, and medical devices were achieved in 2021.
Lindgren et al. demonstrate that following deletion of the collagen XVII immunodominant epitope that is implicated in bullous pemphigoid pathogenesis, most mice paradoxically develop severe itch, skin erosions, and ulceration with dermo-epidermal junction-targeting autoantibodies that are characteristic of bullous pemphigoid, suggesting that absence of the immunodominant domain stimulates IL-17-associated inflammation and an autoimmune response against components of the dermo-epidermal junction.
Coutier et al. show that the transcriptional repressor MXD4/MAD4 is a critical regulator of keratinocyte mitotic activity and immaturity and that maintenance of low levels of this factor led to increased immaturity, proliferation, and clonogenic potential of keratinocyte precursors in a 3-D epidermis organoid culture, highlighting the utility of this pro-stemness factor for maintaining the regenerative capacity of cells amplified in culture.
De Logu et al. report that miR-203b-3p, an miRNA that is upregulated in psoriasis, functions as an itch promoter via activation of the 5-HTR2B/TRPV4 neuronal pathway. By computer simulation the investigators found that miR-203b-3p directly interacts with the extracellular portion of 5-HTR2B and induces its activation. These result underscore the relevance of extracellular miRNA in itch in inflammatory skin diseases and the potential to modulate itch via these molecules.
The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information.
The European Society for Dermatological Research (ESDR) supports research toward understanding skin homeostasis improving the health of patients suffering from skin and venereal disease, infectious diseases and immune-mediated and inflammatory disorders.