Acne and Telomere Length: A New Spectrum between Senescence and Apoptosis Pathways

Open ArchivePublished:September 27, 2016DOI:https://doi.org/10.1016/j.jid.2016.09.014
      Acne is a multifactorial disease with many factors thought to play a role, including skin microflora and nutrition as well as hormonal influences and stress (
      • Suh D.H.
      • Kwon H.H.
      What’s new in the physiopathology of acne?.
      ). Acne patients have increased sebum secretion, and both acne and activity of the sebaceous glands are under significant genetic control (
      • Bataille V.
      • Snieder H.
      • MacGregor A.J.
      • Sasieni P.
      • Spector T.D.
      The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women.
      ,
      • Mourelatos K.
      • Eady E.A.
      • Cunliffe W.J.
      • Clark S.M.
      • Cove J.H.
      Temporal changes in sebum excretion and propionibacterial colonization in preadolescent children with and without acne.
      ). Recent genome-wide association studies have identified several variants linked to acne susceptibility (
      • He L.
      • Wu W.J.
      • Yang J.K.
      • Cheng H.
      • Zuo X.B.
      • Lai W.
      • et al.
      Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.
      ,
      • Navarini A.A.
      • Simpson M.A.
      • Weale M.
      • Knight J.
      • Carlavan I.
      • Reiniche P.
      • et al.
      Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
      ,
      • Wang H.
      • Guo M.
      • Shen S.
      • He L.
      • Zhang X.
      • Zuo X.
      • et al.
      Variants in SELL, MRPS36P2, TP63, DDB2, CACNA1H, ADAM19, GNAI1, CDH13 and GABRG2 interact to confer risk of acne in Chinese population.
      ,
      • Zhang M.
      • Qureshi A.A.
      • Hunter D.J.
      • Han J.
      A genome-wide association study of severe teenage acne in European Americans.
      ).

      Abbreviations:

      kb ( kilobase pair), LTL ( leukocyte telomere length), SNP ( single-nucleotide polymorphism)

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