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JID VisualDx Quiz: July 2013

      JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx's vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.

      QUESTIONS

      • What is your diagnosis?
        • a.
          Rothmund–Thomson syndrome.
        • b.
          Hutchinson–Gilford syndrome.
        • c.
          Werner syndrome.
        • d.
          Aplasia cutis congenita.
        • e.
          Anhidrotic ectodermal dysplasia.
      • Which factors are important for progerin expression?
        • a.
          Advanced age.
        • b.
          UVB exposure.
        • c.
          Gender.
        • d.
          Chronic UVA exposure.
        • e.
          Race.
      • Support for a shared mechanism for photoaging and intrinsic aging include the following:
        • a.
          Older adults having increased progerin.
        • b.
          Acute exposure of UV increasing progerin expression.
        • c.
          Progerin expression being elevated in progeria.
        • d.
          Normalization of increased progerin expression being delayed in older adults.
        • e.
          All of the above.

      TOPIC ARTICLE

      Answers to the questions are available in the supplementary material online.
      Supplementary material is available at http://dx.doi.org/10.1038/jid.2013.217
      Additional images related to this condition and the differential diagnosis may be found at http://info.visualdx.com/l/11412/2013-04-10/s2mhp.
      Questions 2 and 3 refer to the following article:

      REFERENCES

        • Takeuchi H.
        • Rünger T.M.
        Longwave UV light induces the aging-associated progerin.
        J Invest Dermatol. 2013; 133: 1857-1862