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JID VisualDx Quiz| Volume 134, ISSUE 12, P1-2, December 2014

JID VisualDx Quiz: December 2014

      JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx's vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
      Figure thumbnail fx1
      Image appears with permission from VisualDx. © Logical Images, Inc.

      QUESTIONS

      • 1.
        What is your diagnosis?
        • a.
          Bullous pemphigoid.
        • b.
          Epidermolysis bullosa acquista.
        • c.
          Bullous drug reaction.
        • d.
          Linear IgA bullous dermatosis.
        • e.
          Bullous contact dermatitis.
      • 2.
        Increased IL-17 in blister fluid in bullous pemphigoid is most likely derived from what?
        • a.
          T helper type 17 (Th17) cells.
        • b.
          Neutrophils.
        • c.
          Th2 cells.
        • d.
          Langerhans cells.
        • e.
          All of the above.
      • 3.
        IL-17 leads to an increase in which of the following, which may maintain lesion development in bullous pemphigoid?
        • a.
          Neutrophil elastase.
        • b.
          Matrix metalloprotease-9.
        • c.
          ADAM 12.
        • d.
          Both a and b.
        • e.
          All of the above.

      TOPIC ARTICLE

      Questions 2 and 3 refer to the following article:
      Answers are available as supplementary material athttp://dx.doi.org/10.1038/jid.2014.435.html

      REFERENCES

        • Le Jan S.
        • Plée J.
        • Vallerand D.
        • et al.
        Innate immune cell–produced IL-17 sustains inflammation in bullous pemphigoid.
        J Invest Dermatol. 2014; 134: 2908-2917