Cells to Surgery Quiz| Volume 134, ISSUE 12, P1-2, December 2014

Cells to Surgery Quiz: December 2014

      Figure thumbnail fx1
      Image appears with permission from VisualDx. © Logical Images, Inc.


      • 1.
        A 10-year-old black female presents with the lesions pictured above. She has similar-looking lesions in the antecubital fossa bilaterally. What is the most likely diagnosis?
        • a.
          Atopic dermatitis.
        • b.
        • c.
          Irritant contact dermatitis.
        • d.
          Seborrheic dermatitis.
      • 2.
        What is the proposed mechanism of action of excimer lamp irradiation in decreasing pruritus associated with this patient’s skin condition?
        • a.
          Improves skin barrier function.
        • b.
          Decreases pruritogenic immune response.
        • c.
          Placebo effect.
        • d.
          Antihyperinnervative effect on epidermal keratinocytes.
      • 3.
        What is the effect of adding a cutoff excimer filter to the excimer lamp?
        • a.
          Loss of antipruritic effect.
        • b.
          Decreased DNA damage to epidermal keratinocytes.
        • c.
          Increased production of cyclobutane pyrimidine dimers by epidermal keratinocytes.
        • d.
          Increased expression of nicotinamide mononucleotide adenylyl transferase-2 compared with control.


      The questions refer to the following articles:


        • Kamo A.
        • Tominaga M.
        • Kamata Y.
        • et al.
        The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model.
        J Invest Dermatol. 2014; 134: 2977-2984