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JID VisualDx Quiz: July 2014

      QUESTIONS

      • 1.
        What is your diagnosis?
        • a.
          Systemic sclerosis.
        • b.
          Graft-versus-host disease.
        • c.
          Scleredema.
        • d.
          Morphea.
        • e.
          Nephrogenic systemic fibrosis.
      • 2.
        Benefits of skin-specific ablation of mast cells (compared with other models of mast-cell elimination) include the following (choose all that apply):
        • a.
          Superior removal of all mast cells.
        • b.
          Clarification of contradictory results of other mast-cell models.
        • c.
          Ability to examine skin-specific effects of mast cells.
        • d.
          Allows examination of mast-cell trafficking.
        • e.
          All of the above.
      • 3.
        Based on the above work, which is true about the role of mast cells in repair?
        • a.
          Critical for wound healing.
        • b.
          Possibly needed but redundancy exists.
        • c.
          Without mast cells scarring is prevented.
        • d.
          Without mast cells scarring is increased.
        • e.
          None of the above.

      TOPIC ARTICLE

      Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.214.
      Additional images related to this condition and the differential diagnosis may be found at: http://info.visualdx.com/l/11412/2014-05-02/vx3yw

      Questions 2 and 3 refer to the following article:

        • Willenborg S.
        • Eckes B.
        • Brinckmann J.
        • et al.
        Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis.
        J Invest Dermatol. 2014; 134: 2005-2015