Advertisement

Effects of 13-Cis-Retinoic Acid on the Hamster Meibomian Gland

      This paper is only available as a PDF. To read, Please Download here.
      Systemic administration of 13-cis-retinoic acid caused a reduction of acinar tissue in the hamster meibomian gland. Histologic examination of treated meibomian gland tissue revealed a thickening of gland ductal epithelium and a decrease in the numbers of mature lipid-laden acinar cells. Morphometric analysis showed a reduction of up to 75% in mean volume of meibomian acinar tissue from animals fed a high dose of 13-cis-retinoic acid. Clinical observations in these animals included alopecia and weight loss. Ocular complications included crusting of the eyelid margin and the external surface of the lid and erythema of the conjunctiva. The model supports previous observations by the authors that systemic 13-cis-retinoic acid affects meibomian gland structure in a laboratory animal. The ocular side effects described in this model suggest that future functional studies may yield important insights into the complex relationship between meibomian gland morphology and function, and events on the ocular surface.

      References

        • Gomez E.C.
        Actions of isotretinoin and etretinate on the pilosebaceous unit.
        J Am Acad Dermatol. 1982; 6: 746-750
        • Jester J.V.
        • Rife L.
        • Nii D.
        • Luttrull J.K.
        • Wilson L.
        • Smith R.E.
        In vivo biomicroscopy and photography of meibomian glands in a rabbit model of meibomian gland dysfunction.
        Invest Ophthalmol Vis Sci. 1982; 22: 660-667
        • Kamm J.
        Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids.
        J Am Acad Dermatol. 1982; 6: 652-659
        • Weissmann A.
        • Bowden J.
        • Frank B.
        • Horwitz S.N.
        • Frost P.
        Morphometric studies of the hamster flank organ: An improved model to evaluate pharmacologic effects on sebaceous glands.
        J Invest Dermatol. 1984; 82: 522-525
        • Plewig G.
        • Wagner A.
        • Nikolowski J.
        • Landthaler M.
        Effects of two retinoids in animal experiments and after clinical application in acne patients: 13-cis-retinoic Ro 4-3780 and aromatic retinoid Ro 10-9359.
        in: Orfanos C.E. Retinoids: Advances in Basic Research and Therapy. Springer-Verlag, New York1981: 219-235
        • Lambert R.W.
        • Smith R.E.
        Pathogenesis of blepharoconjunctivitis complicating 13-cis-retinoic acid therapy in a laboratory model.
        Invest Ophthalmol Vis Sci. 1988; 29: 1559-1564
        • Milson J.
        • Jones D.H.
        • King K.
        • Cunliffe W.J.
        Ophthalmological effects of 13-cis-retinoic acid therapy for acne vulgaris.
        Br J Dermatol. 1982; 107: 491
        • Fraunfelder F.T.
        • LaBraico J.M.
        • Meyer S.M.
        Adverse ocular reactions possibly associated with isotretinoin.
        Am J Ophthalmol. 1985; 100: 534-537
        • Blackman H.J.
        • Peck G.L.
        • Olsen T.G.
        • Bergsma D.R.
        Blepharoconjunctivitis: A side effect of 13-cis-retinoic acid therapy for dermatologic diseases.
        Ophthalmology. 1979; 86: 753-758
        • Landthaler M.
        • Kummermehr J.
        • Wagner A.
        • Plewig G.
        Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands.
        Arch Dermatol Res. 1980; 269: 297-309
        • Landthaler M.
        • Kummermehr J.
        • Wagner A.
        • Plewig G.
        13-cis-retinoic acid inhibits sebaceous glands in animals and humans: Planimetry and in-vitro-autoradiography.
        J Invest Dermatol. 1980; 74: 453