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An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata

Published:November 03, 2017DOI:https://doi.org/10.1016/j.jid.2017.07.827
      Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for.

      Abbreviations:

      AA (alopecia areata), PRP (platelet-rich plasma), TAC (triamcinolone acetonide)
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      References

        • Albanese A.
        • Licata M.E.
        • Polizzi B.
        • Campisi G.
        Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration.
        Immun Ageing. 2013; 10: 23
        • Alkhalifah A.
        • Alsantali A.
        • Wang E.
        • McElwee K.J.
        • Shapiro J.
        Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis.
        J Am Acad Dermatol. 2010; 62: 177-188
        • Alkhalifah A.
        • Alsantali A.
        • Wang E.
        • McElwee K.J.
        • Shapiro J.
        Alopecia areata update: part II. Treatment.
        J Am Acad Dermatol. 2010; 62: 191-202
        • Arora S.
        • Gupta P.B.
        Automated microneedling device—a new tool in dermatologist's kit—a review.
        J Pak Med Assoc. 2012; 22: 354-357
        • Blair P.
        • Flaumenhaft R.
        Platelet α-granules: basic biology and clinical correlates.
        Blood Rev. 2009; 23: 177-189
        • Chandrashekar B.S.
        • Sandeep M.A.
        • Vani Vasanth J.P.
        • Rajashekar M.L.
        Triamcinolone acetonide mesotherapy in the treatment of recalcitrant patches of alopecia areata—a pilot study.
        J Clin Dermatol Ther. 2015; 2: 1-4
        • Chandrashekar B.
        • Yepuri V.
        • Mysore V.
        Alopecia areata-successful outcome with microneedling and triamcinolone acetonide.
        J Cutan Aesthet Surg. 2014; 7: 63-64
        • Cieslik-Bielecka A.
        • Choukroun J.
        • Odin G.
        • M Dohan Ehrenfest D.
        L-PRP/L-PRF in esthetic plastic surgery, regenerative medicine of the skin and chronic wounds.
        Curr Pharm Biotechnol. 2012; 13: 1266-1277
        • Danilenko D.M.
        • Ring B.D.
        • Yanagihara D.
        • Benson W.
        • Wiemann B.
        • Starnes C.O.
        • et al.
        Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.
        Am J Pathol. 1995; 147: 145-154
        • DelRossi A.J.
        • Cernaianu A.C.
        • Vertrees R.A.
        • Wacker C.J.
        • Fuller S.J.
        • Cilley Jr., J.H.
        • et al.
        Platelet-rich plasma reduces postoperative blood loss after cardiopulmonary bypass.
        J Thorac Cardiovasc Surg. 1990; 100: 281-286
        • Dhurat R.
        • Sukesh M.S.
        • Avhad G.
        • Dandale A.
        • Pal A.
        • Pund P.
        A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: a pilot study.
        Int J Trichology. 2013; 5: 6
        • Donovan J.
        Successful treatment of corticosteroid-resistant ophiasis-type alopecia areata (AA) with platelet-rich plasma (PRP).
        JAAD Case Rep. 2015; 1: 305-307
        • Driskell R.R.
        • Clavel C.
        • Rendl M.
        • Watt F.M.
        Hair follicle dermal papilla cells at a glance.
        J Cell Sci. 2011; 124: 1179-1182
        • Eppley B.L.
        • Woodell J.E.
        • Higgins J.
        Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing.
        Plast Reconstr Surg. 2004; 114: 1502-1508
        • Ito M.
        • Yang Z.
        • Andl T.
        • Cui C.
        • Kim N.
        • Millar S.E.
        • et al.
        Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.
        Nature. 2007; 447: 316-320
        • Kim H.M.
        • Lim Y.Y.
        • An J.H.
        • Kim M.N.
        • Kim B.J.
        Transdermal drug delivery using disk microneedle rollers in a hairless rat model.
        Int J Dermatol. 2012; 51: 859-863
        • Kim Y.S.
        • Jeong K.H.
        • Kim J.E.
        • Woo Y.J.
        • Kim B.J.
        • Kang H.
        Repeated microneedle stimulation induces enhanced hair growth in a murine model.
        Ann Dermatol. 2016; 28: 586-592
        • Kumaran M.S.
        Platelet-rich plasma in dermatology: boon or a bane?.
        Indian J Dermatol Venereol Leprol. 2014; 80: 5
        • Li Z.J.
        • Choi H.I.
        • Choi D.K.
        • Sohn K.C.
        • Im M.
        • Seo Y.J.
        • et al.
        Autologous platelet-rich plasma: a potential therapeutic tool for promoting hair growth.
        Dermatol Surg. 2012; 38: 1040-1046
        • Lynch M.D.
        • Bashir S.
        Applications of platelet-rich plasma in dermatology: a critical appraisal of the literature.
        J Dermatolog Treat. 2016; 27: 285-289
        • Maria-Angeliki G.
        • Alexandros-Efstratios K.
        • Dimitris R.
        • Konstantinos K.
        Platelet-rich plasma as a potential treatment for noncicatricial alopecias.
        Int J Trichology. 2015; 7: 54-63
        • Mubki T.
        Platelet-rich plasma combined with intralesional triamcinolone acetonide for the treatment of alopecia areata: a case report.
        J Dermatol Dermatol Surg. 2016; 20: 87-90
        • Myung P.S.
        • Takeo M.
        • Ito M.
        • Atit R.P.
        Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration.
        J Invest Dermatol. 2013; 133: 31-41
        • Schiavone G.
        • Raskovic D.
        • Greco J.
        • Abeni D.
        Platelet-rich plasma for androgenetic alopecia: a pilot study.
        Dermatol Surg. 2014; 40: 1010-1019
        • Shumez H.
        • Prasad P.V.S.
        • Kaviarasan P.K.
        • Deepika R.
        Intralesional platelet rich plasma vs intralesional triamcinolone in the treatment of alopecia areata: a comparative study.
        Int J Med Res Health Sci. 2015; 4: 118-122
        • Singh S.
        Role of platelet-rich plasma in chronic alopecia areata: our centre experience.
        Indian J Plast Surg. 2015; 48: 57
        • Trink A.
        • Sorbellini E.
        • Bezzola P.
        • Rodella L.
        • Rezzani R.
        • Ramot Y.
        • et al.
        A randomized, double-blind, placebo-and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata.
        Br J Dermatol. 2013; 169: 690-694
        • Uebel C.O.
        • da Silva J.B.
        • Cantarelli D.
        • Martins P.
        The role of platelet plasma growth factors in male pattern baldness surgery.
        Plast Reconstr Surg. 2006; 118: 1458-1466