Ganoderma lucidum has been used in China as a herbal medicine. Several studies suggested that Ganodermal lucidum polysaccharides have anti-tumor activities and anti-oxidation effects. This study was conducted to investigate the protective effect of G.lucidium in UVB-induced human fibroblasts and skin equivalent models. Fibroblasts exposed UVB increased MMP-1 protein expression and decreased procollagen protein expression. Treatment with G. lucidium inhibited UVB-induced MMP-1 expression and increased procollagen expression. Extracellular signal regulated kinase (ERK) activation was inhibited by treatment with G. lucidium. In addition, G. lucidium increased collagen expression in UVB-induced skin equivalent models analyzed by multiphoton microscopy. These results demonstrated that G. lucidium can inhibit UVB-induced MMP-1 expression by inhibiting the ERK pathways.
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