038 Gastrointestinal amyloidosis by long-lasting inflammatory skin disease

      We recently demonstrated that persistent release of IL-1ab from inflammatory skin causes weight loss, vascular sclerotic changes, and severe systemic amyloidosis in multiple organs. We addressed this question by using skin inflammatory mouse model, keratin-14 driven caspase-1 transgenic mice (KCASP1Tg). In inflammatory diseases such as rheumatoid arthritis, secondary intestinal amyloidosis occurs which causes malabsorption and bowel movement obstruction. Also in KCASP1Tg mice, long-lasting expression of IL-1β causes gastrointestinal amyloidosis. Usually, gastrointestinal amyloidosis is irreversible in many cases and early treatment of primary disease is most important for prevention it. Here, we investigated which anti cytokine antibody is effect for prevention of gastrointestinal amyloidosis.