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CD1-Restricted T Cells in Inflammatory Skin Diseases

      Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.

      Abbreviations:

      AD (atopic dermatitis), APC (antigen-presenting cell), DC (dendritic cell), HDM (house dust mite), ILC2 (group 2 innate lymphoid cell), KC (keratinocyte), LC (Langerhans cell), PLA (phospholipase A), SCID (severe combined immunodeficient), Th (T helper type)
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