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The Psoriatic Nonlesional Skin: A Battlefield between Susceptibility and Protective Factors

  • Author Footnotes
    5 These authors contributed equally to this work.
    Evelyn Kelemen
    Footnotes
    5 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    Department of Medical Genetics, Faculty of Medicine, University of Szeged, Szeged, Hungary
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  • Author Footnotes
    5 These authors contributed equally to this work.
    Renáta Bozó
    Footnotes
    5 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    Hungarian Centre of Excellence for Molecular Medicine, University of Szeged, Skin Research Group, Szeged, Hungary
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  • Gergely Groma
    Affiliations
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Szeged, Hungary
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  • Zsuzsanna Bata-Csörgő
    Affiliations
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    Hungarian Centre of Excellence for Molecular Medicine, University of Szeged, Skin Research Group, Szeged, Hungary

    MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Szeged, Hungary
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  • Lajos Kemény
    Affiliations
    Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Szeged, Hungary

    Hungarian Centre of Excellence for Molecular Medicine, University of Szeged, Skin Research Group, Szeged, Hungary

    MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Szeged, Hungary
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  • Author Footnotes
    6 These authors contributed equally to this work.
    Judit Danis
    Correspondence
    Correspondence: Judit Danis, Department of Dermatology and Allergology, Faculty of Medicine, University of Szeged, Korányi fasor 6, 6720 Szeged, Hungary.
    Footnotes
    6 These authors contributed equally to this work.
    Affiliations
    Department of Medical Genetics, Faculty of Medicine, University of Szeged, Szeged, Hungary

    Hungarian Centre of Excellence for Molecular Medicine, University of Szeged, Skin Research Group, Szeged, Hungary

    MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Szeged, Hungary
    Search for articles by this author
  • Author Footnotes
    6 These authors contributed equally to this work.
    Márta Széll
    Footnotes
    6 These authors contributed equally to this work.
    Affiliations
    Department of Medical Genetics, Faculty of Medicine, University of Szeged, Szeged, Hungary

    MTA-SZTE Dermatological Research Group, Eötvös Loránd Research Network, Szeged, Hungary
    Search for articles by this author
  • Author Footnotes
    5 These authors contributed equally to this work.
    6 These authors contributed equally to this work.
      In the last two decades, large-scale gene-expression studies on psoriatic skin samples revealed that even though nonlesional skin is macroscopically identical to healthy skin, it harbors several molecular differences. Originally, these molecular differences were thought to represent susceptibility factors for plaque formation. However, we review in this paper the several factors of immune regulation and structural alteration that are specific for the nonlesional skin and serve as protective factors by counteracting plaque formation and contributing to the maintenance of the nonlesional phenotype.

      Abbreviations:

      DC (dendritic cell), ECM (extracellular matrix), EDA+FN (extra domain A–containing fibronectin), KC (keratinocyte), lncRNA (long noncoding RNA), miRNA (microRNA), MMP (matrix metalloproteinase), ncRNA (noncoding RNA), NET (neutrophil extracellular trap), PRINS (psoriasis-related noncoding RNA induced by stress)
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