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Transcriptomic Analysis of Blaschko-Linear Psoriasis Reveals Shared and Distinct Features with Psoriasis Vulgaris

      Psoriasis is a common chronic inflammatory skin disease characterized by abnormal proliferation/differentiation of keratinocytes (KCs) and increased immune cell infiltration in the dermis and epidermis (
      • Greb J.E.
      • Goldminz A.M.
      • Elder J.T.
      • Lebwohl M.G.
      • Gladman D.D.
      • Wu J.J.
      • et al.
      Psoriasis.
      ). Although immune cells are considered to be the main driver of psoriasis, KCs may also be implicated in triggering psoriasis and in sustaining inflammation in psoriatic skin (
      • Ni X.
      • Lai Y.
      Keratinocyte: a trigger or an executor of psoriasis?.
      ). Psoriasis can manifest clinically in several different ways (
      • Boehncke W.H.
      • Schön M.P.
      Psoriasis.
      ), but the rare observation that some individuals may present with psoriasis along the lines of Blaschko (
      • Blaschko A.
      Die Nervenverteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut.
      ), that is, in a distribution fitting lines of epidermal development and therefore inherent KC pathology (
      • Happle R.
      Mosaicism in human skin. Understanding the patterns and mechanisms.
      ), provides an opportunity to dissect KC pathobiology in psoriasis in more detail.

      Abbreviations:

      BLP (Blaschko-linear psoriasis), DE (differentially expressed), KC (keratinocyte), PV (psoriasis vulgaris)
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