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Altered Skin and Gut Microbiome in Hidradenitis Suppurativa

  • Author Footnotes
    6 These authors contributed equally to this work.
    Siobhán McCarthy
    Correspondence
    Correspondence: Siobhán McCarthy, Department of Dermatology, South Infirmary Victoria University Hospital, Old Blackrock Road, Cork T12 X23H, Ireland.
    Footnotes
    6 These authors contributed equally to this work.
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland

    Department of Dermatology, South Infirmary Victoria University Hospital, Cork, Ireland
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  • Author Footnotes
    6 These authors contributed equally to this work.
    Maurice Barrett
    Footnotes
    6 These authors contributed equally to this work.
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland

    School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
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  • Shivashini Kirthi
    Affiliations
    Department of Dermatology, Tallaght University Hospital, Dublin, Ireland
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  • Paola Pellanda
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland

    School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
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  • Klara Vlckova
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland

    School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
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  • Anne-Marie Tobin
    Affiliations
    Department of Dermatology, Tallaght University Hospital, Dublin, Ireland
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  • Michelle Murphy
    Affiliations
    Department of Dermatology, South Infirmary Victoria University Hospital, Cork, Ireland

    School of Medicine, University College Cork, National University of Ireland, Cork, Ireland
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  • Fergus Shanahan
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland
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  • Paul W. O’Toole
    Affiliations
    APC Microbiome Ireland, University College Cork, National University of Ireland, Cork, Ireland

    School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland
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  • Author Footnotes
    6 These authors contributed equally to this work.
Published:August 05, 2021DOI:https://doi.org/10.1016/j.jid.2021.05.036
      Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistulae at intertriginous sites. The skin–gut axis is an area of emerging research in inflammatory skin disease and is a potential contributory factor to the pathogenesis of HS. A total of 59 patients with HS provided fecal samples and nasal and skin swabs of affected sites for analysis. A total of 30 healthy controls provided fecal samples, and 20 healthy controls provided nasal and skin swabs. We performed bacterial 16S ribosomal RNA gene amplicon sequencing on total DNA derived from the samples. Microbiome alpha diversity was significantly lower in the fecal, skin, and nasal samples of individuals with HS, which may be secondary to disease biology or related to antibiotic usage. Ruminococcus gnavus was more abundant in the fecal microbiome of individuals with HS, which is also reported in Crohn’s disease, suggesting comorbidity due to shared gut microbiota alterations. Finegoldia magna was overabundant in HS skin samples relative to that in the healthy controls. It is possible that local inflammation is driven by F. magna by promoting the formation of neutrophil extracellular traps. These alterations in both the gut and skin microbiome in HS warrant further exploration, and therapeutic strategies, including fecal microbiota transplant or bacteriotherapy, could be of benefit.

      Abbreviations:

      ASV (amplicon sequence variant), BMI (body mass index), CD (Crohn’s disease), HS (hidradenitis suppurativa), IBD (inflammatory bowel disease)
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