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Regulation of IL-17A–Producing Cells in Skin Inflammatory Disorders

  • Pushpa Pandiyan
    Correspondence
    Correspondence: Pushpa Pandiyan, Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, 44106, Cleveland, Ohio, USA.
    Affiliations
    Department of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio, USA

    Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Search for articles by this author
  • Thomas S. McCormick
    Affiliations
    Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Search for articles by this author
Published:September 21, 2021DOI:https://doi.org/10.1016/j.jid.2021.06.036
      This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and how they are involved in cutaneous pathogenic responses. It will also discuss cutaneous dysbiosis and FOXP3+ regulatory T cells in the context of inflammatory conditions linked to IL-17 responses in the skin. Specifically, it will review key literature on chronic mucocutaneous candidiasis and psoriasis.

      Abbreviations:

      AMP (antimicrobial peptide), APECED (autoimmune polyendocrinopathy candidiasis ectodermal dysplasia), CMC (chronic mucocutaneous candidiasis), DC (dendritic cell), HIES (hyper-IgE syndrome), KC (keratinocyte), MAIT (mucosa-associated invariant T), STAT (signal transducer and activator of transcription), Th (T helper type), TLR (toll-like receptor), Treg (regulatory T cell)
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