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Neuron‒Mast Cell Cross-Talk in the Skin

  • Author Footnotes
    3 These authors contributed equally to this work.
    Shiqun Zhang
    Footnotes
    3 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
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  • Author Footnotes
    3 These authors contributed equally to this work.
    Tina L. Sumpter
    Footnotes
    3 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Search for articles by this author
  • Daniel H. Kaplan
    Correspondence
    Correspondence: Daniel H. Kaplan, Departments of Dermatology and Immunology, University of Pittsburgh, BST W1043, 200 Lothrop Street, Pittsburgh, Pennsylvania 15216, USA.
    Affiliations
    Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Search for articles by this author
  • Author Footnotes
    3 These authors contributed equally to this work.
Published:November 06, 2021DOI:https://doi.org/10.1016/j.jid.2021.10.006
      Skin-resident mast cells (MCs) and cutaneous sensory neurons both play crucial roles in microbial‒host defense and inflammatory diseases. MCs can be directly activated by pathogens or their products, resulting in the release of numerous mediators that promote innate immune responses and also activate sensory neurons. Cutaneous sensory neurons can also directly detect the presence of pathogens, resulting in the release of neuropeptides that modulate MC function. In this review, we will focus on the reciprocal interactions between cutaneous sensory neurons and MCs and the importance of this cross-talk in skin diseases.

      Abbreviations:

      AD (atopic dermatitis), DRG (dorsal root ganglion), KC (keratinocyte), LC (Langerhans cell), MC (mast cell), NPPB (natriuretic peptide B), SST (somatostatin), VIP (vasoactive intestinal peptide)
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