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The Commensal Staphylococcus warneri Makes Peptide Inhibitors of MRSA Quorum Sensing that Protect Skin from Atopic or Necrotic Damage

      The opportunistic pathogen Staphylococcus aureus accounts for the majority of all skin and soft tissue infections in the United States and infects 30–100% of atopic dermatitis (AD) lesions (
      • Geoghegan J.A.
      • Irvine A.D.
      • Foster T.J.
      Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship.
      ;
      • Parlet C.P.
      • Brown M.M.
      • Horswill A.R.
      Commensal staphylococci influence Staphylococcus aureus skin colonization and disease.
      ). Conversely, S. aureus only transiently colonizes healthy skin, suggesting that this pathogen may be actively excluded from this environment (
      • Geoghegan J.A.
      • Irvine A.D.
      • Foster T.J.
      Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship.
      ). Healthy human skin is home to a diverse community of normal flora, including the coagulase-negative staphylococci (CoNS), and many CoNS directly compete with S. aureus through a variety of mechanisms to maintain skin homeostasis and colonization resistance (
      • Parlet C.P.
      • Brown M.M.
      • Horswill A.R.
      Commensal staphylococci influence Staphylococcus aureus skin colonization and disease.
      ).

      Abbreviations:

      AD (atopic dermatitis), agr (accessory gene regulator), AIP (autoinducing peptide), CM (conditioned media), CoNS (coagulase-negative staphylococci), MRSA (methicillin‒resistant Staphyloccocus aureus)
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      Supplementary Reference

        • Todd D.A.
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        • Horswill A.R.
        • Cech N.B.
        Hybrid Quadrupole-Orbitrap mass spectrometry for quantitative measurement of quorum sensing inhibition.
        J Microbiol Methods. 2016; 127: 89-94