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Disease-Defining Molecular Features of Primary Cutaneous B-Cell Lymphomas: Implications for Classification and Treatment

  • Yue Zhang
    Affiliations
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA

    Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA
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  • Tessa M. LeWitt
    Affiliations
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA
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  • Abner Louissaint Jr.
    Affiliations
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA

    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
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  • Joan Guitart
    Affiliations
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA
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  • Author Footnotes
    5 These authors contributed equally as senior authors.
    Xiaolong Alan Zhou
    Footnotes
    5 These authors contributed equally as senior authors.
    Affiliations
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA
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  • Author Footnotes
    5 These authors contributed equally as senior authors.
    Jaehyuk Choi
    Correspondence
    Correspondence: Jaehyuk Choi, Department of Dermatology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Medical Research Center, 303 East Superior Street, Room 5-115, Chicago, Ilinois 60611, USA.
    Footnotes
    5 These authors contributed equally as senior authors.
    Affiliations
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA

    Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Ilinois, USA
    Search for articles by this author
  • Author Footnotes
    5 These authors contributed equally as senior authors.
Published:September 24, 2022DOI:https://doi.org/10.1016/j.jid.2022.07.027
      Primary cutaneous B-cell lymphoma—primary cutaneous follicle center lymphoma; primary cutaneous marginal zone lymphoma; and primary cutaneous diffuse large B-cell, leg type—is a heterogeneous group with a variety of clinical and histological presentations. Until recently, the molecular bases of these disease subtypes have been unclear. We and others have identified the specific genetic characteristics that distinguish these subtypes from their respective systemic counterparts. These molecular features can improve diagnoses, determine the likelihood of concurrent or future systemic disease, and enable the rational design of novel clinical trials.

      Abbreviations:

      ABC (activated B-cell), CBCL (cutaneous B-cell lymphoma), DLBCL (diffuse large B-cell lymphoma), FL (follicular lymphoma), GC (germinal center), GCB (germinal center B), MALT (mucosa-associated lymphoid tissue), MHC (major histocompatibility complex), MZL (marginal zone lymphoma), PCDLBCL-LT (primary cutaneous diffuse large B-cell lymphoma, leg type), PCFCL (primary cutaneous follicle center lymphoma), PCNSL (primary central nervous system lymphoma), PCMZL (primary cutaneous marginal zone lymphoma), SS-PCFCL (secondary systemic primary cutaneous follicle center lymphoma), STAT (transducer and activator of transcription), Th (T helper)
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