Reactive oxygen species (ROS) are generated during oxidative metabolism and cellular
response to external stressors and can potentiate keratinocyte carcinogenesis (
Ray et al., 2012
). ROS can be scavenged by antioxidants, including vitamin C. In vitro and in vivo studies have shown that vitamin C prevents oxidative damage to keratinocytes, which
could help prevent the formation of cutaneous squamous cell carcinoma (cSCC) (
Kawashima et al., 2018
,
Pauling et al., 1982
). However, epidemiologic studies have shown conflicting effects of vitamin C exposure
on cSCC risk (
Asgari et al., 2011
,
Fung et al., 2003
,
Hercberg et al., 2007
). Observational studies may have revealed conflicting results due to residual confounding.
Thus, the association between serum vitamin C and cSCC risk needs further study with
a method that minimizes the impact of residual confounding.Key Words
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Article Info
Publication History
Accepted:
October 4,
2022
Received in revised form:
September 30,
2022
Received:
February 19,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
