ROS are generated during oxidative metabolism and cellular response to external stressors
and can potentiate keratinocyte carcinogenesis (
Ray et al., 2012
). ROS can be scavenged by antioxidants, including vitamin C. In vitro and in vivo
studies have shown that vitamin C prevents oxidative damage to keratinocytes, which
could help prevent the formation of cutaneous squamous cell carcinoma (cSCC) (
Kawashima et al., 2018
;
Pauling et al., 1982
). However, epidemiologic studies have shown conflicting effects of vitamin C exposure
on cSCC risk (
Asgari et al., 2011
;
Fung et al., 2003
;
Hercberg et al., 2007
). Observational studies may have revealed conflicting results owing to residual confounding.
Thus, the association between serum vitamin C and cSCC risk needs further study with
a method that minimizes the impact of residual confounding.Abbreviations:
cSCC (cutaneous squamous cell carcinoma), MR (Mendelian randomization)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: November 04, 2022
Accepted manuscript published online XXX; corrected proof published online XXXPublication stage
In Press Journal Pre-ProofIdentification
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© 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
