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Comorbidities in Patients with Vitiligo: A Systematic Review and Meta-Analysis

  • Author Footnotes
    5 These authors contributed equally to this work.
    Ji Hae Lee
    Footnotes
    5 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
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  • Author Footnotes
    5 These authors contributed equally to this work.
    Hyun Jeong Ju
    Footnotes
    5 These authors contributed equally to this work.
    Affiliations
    Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
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  • Ji Min Seo
    Affiliations
    Department of Dermatology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea
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  • Abdurrahman Almurayshid
    Affiliations
    Department of Medicine, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj City, Saudi Arabia
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  • Gyong Moon Kim
    Affiliations
    Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
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  • Khaled Ezzedine
    Affiliations
    Department of Dermatology, Henry Mondor Hospital, Paris Est Créteil University, Créteil, France
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  • Jung Min Bae
    Correspondence
    Correspondence: Jung Min Bae, Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon 16247, Korea.
    Affiliations
    Department of Dermatology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea
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  • Author Footnotes
    5 These authors contributed equally to this work.
Published:November 26, 2022DOI:https://doi.org/10.1016/j.jid.2022.10.021
      Vitiligo has been reported to be associated with a variety of diseases, but it has not been systematically reviewed. Therefore, we aimed to identify prevalent diseases in patients with vitiligo and quantify their associations compared with those in healthy controls. A comprehensive search of MEDLINE and EMBASE from the inception to June 2022 was conducted. Observational studies on prevalent diseases in patients with vitiligo compared with those in healthy controls were included, whereas studies limited to pediatrics or providing only laboratory results were excluded. A total of 78 studies were eligible for analyses. Patients with vitiligo showed higher risks of having comorbid autoimmune and connective tissue diseases, including alopecia areata (OR = 2.63, 95% confidence interval [CI] = 2.50‒2.78), discoid lupus erythematosus (OR = 2.54, 95% CI = 1.74‒3.72), Sjogren’s syndrome (OR = 2.50, 95% CI = 1.98‒3.16), myasthenia gravis (OR = 2.30, 95% CI = 1.74‒3.02), systemic lupus erythematosus (OR = 1.96, 95% CI = 1.52‒2.52), and rheumatoid arthritis (OR = 1.82, 95% CI = 1.55‒2.15). Thyroid diseases, diabetes mellitus, metabolic syndrome, sensorineural hypoacusis, and ophthalmic abnormalities were also more prevalent in patients with vitiligo. In conclusion, vitiligo is associated with various systemic diseases. Physicians should evaluate and manage potential comorbid conditions in patients with vitiligo.

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