ABSTRACT
Psoriasis is a multisystemic inflammatory disorder, mainly involving skin and joints,
which etiopathogenesis is still not completely understood. An association with streptococcal
throat infection has been suggested.
We aim to investigate a correlation between interleukin (IL)-17A and interferon (IFN)-γ
production by T-cells infiltrating skin lesions and Psoriasis Area Severity Index
in 313 psoriasis patients, compared to 252 healthy controls. The phenotype of β-haemolytic streptococci-specific infiltrating T-cells in skin lesions was evaluated and characterized for
IFN-γ, IL-4 and IL-17A production. In addition, peripheral blood mononuclear cells
were tested by ELISpot for IFN-γ and IL-17A following streptococcal antigens exposure.
64 of 313 (20.4%) psoriasis patients had throat streptococcal infection. Of the 3868
skin-derived T-cell clones from psoriasis with streptococcal infection, 66% proliferated
in response to β-haemolytic streptococci antigens. Most of β-haemolytic streptococci specific T-cells displayed Th17 and Th1 phenotypes. Levels of IFN-γ and IL-17A secreted
by skin-infiltrating T cells of psoriatic patients significantly correlated with PASI
score. In β-haemolytic streptococci-positive patients, IFN-γ and IL-17A production by peripheral blood T-cells following
stimulation with streptococcal antigens was quantified by ELISpot. The results obtained
may suggest ELISpot as useful diagnostic tool to identify psoriasis patients that
may deserve antibiotic treatment.
Keywords
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Article info
Publication history
Accepted:
October 6,
2022
Received in revised form:
October 4,
2022
Received:
February 8,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology.
