ABSTRACT
Graphical abstract
Keywords
ABBREVIATIONS:
BMDCS (BONE MARROW-DERIVED DENDRITIC CELLS (BMDCS)), BSA (BODY SURFACE AREA), DCS (DENDRITIC CELLS), DMEM (DULBECCO'S MODIFIED EAGLE'S), DNASE (DEOXYRIBONUCLEASE), ECS (ENDOTHELIAL CELLS), FCS (FETAL CALF SÉRUM (FCS)), GM-CSF (GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR), HACAT (HUMAN KERATINOCYTES CELL LINE), HE (HEMATOXYLIN AND EOSIN), IMQ (IMIQUIMOD), KRT14 (KERATIN 14), KRT17 (KERATIN 17), PAQ (PAQUINIMOD), PASI (PSORIASIS AREA AND SEVERITY INDEX), PFA (PARAFORMALDEHYDE), SCRNA-SEQ (SIGLE CELL RNA SEQUENCING - SCRNASEQ), SDLNS (SKIN-DRAINING LYMPH NODES), TBST (TRIS-BUFFERED SALINE TWEEN), UMAP (UNIFORM MANIFOLD APPROXIMATION AND PROJECTION), UTK (USTEKINUMAB), VSMCS (VASCULAR SMOOTH MUSCLE CELLS (VSMCS))Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Journal of Investigative DermatologyREFERENCES
- Hiding under the skin: Interleukin-17–producing γδ T cells go under the skin? Nature Medicine 2012 18:12.Nature Publishing Group. 2012; 18: 1748-1750
Belle AB Van, Heusch M de, Lemaire MM, Hendrickx E, Warnier G, Dunussi-Joannopoulos K, et al. IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice. The Journal of Immunology. American Association of Immunologists; 2012;188(1):462–469
- Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.British Journal of Dermatology. 2006; 155: 62-66
Björk P, Björk A, Vogl T, Stenström M, Liberg D, Olsson A, et al. Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides. PLOS Biology. Public Library of Science; 2009;7(4):e1000097
Boehncke WH, Schön MP. Psoriasis. The Lancet. Lancet Publishing Group; 2015. p. 983–994
Brodmerkel C, Li K, Garcet S, Hayden K, Chiricozzi A, Novitskaya I, et al. Modulation of inflammatory gene transcripts in psoriasis vulgaris: Differences between ustekinumab and etanercept. J Allergy Clin Immunol. J Allergy Clin Immunol; 2019;143(5):1965–9 Available from: https://pubmed.ncbi.nlm.nih.gov/30703387/
- Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation.Immunity. 2011; 35: 596-610
- Interleukin 17 Promotes Expression of Alarmins S100A8 and S100A9 During the Inflammatory Response of Keratinocytes.Front Immunol. Frontiers Media S.A. 2021; 11: 3831
Croxford AL, Karbach S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, et al. IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. J Invest Dermatol. J Invest Dermatol; 2014;134(3):728–735 Available from: https://pubmed.ncbi.nlm.nih.gov/24067382/
- Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochimica et biophysica acta.Biochim Biophys Acta. 1999; 1450: 191-231
van der Fits L, Mourits S, Voerman JSA, Kant M, Boon L, Laman JD, et al. Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis. The Journal of Immunology. The American Association of Immunologists; 2009;182(9):5836–5845 Available from: https://pubmed.ncbi.nlm.nih.gov/19380832/
Frank Nestle PO, Kaplan DH, Barker J. Psoriasis. http://dx.doi.org/10.1056/NEJMra0804595. Massachusetts Medical Society ; 2009;361(5):496–509 Available from: https://www.nejm.org/doi/full/10.1056/nejmra0804595
Ghoreschi K, Balato A, Enerbäck C, Sabat R. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. The Lancet. Elsevier; 2021;397(10275):754–66 Available from: http://www.thelancet.com/article/S0140673621001847/fulltext
- Psoriasis. Nature Reviews Disease Primers.Nature Publishing Group. 2016; 2: 1-17
Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN. Psoriasis. The Lancet. Elsevier; 2021;397(10281):1301–15 Available from: http://www.thelancet.com/article/S0140673620325496/fulltext
Handgretinger H, Andreas Bethge W, Christian Gille U, Feuchtinger T, Lang P, Federmann R, et al. Graft-versus-Host Disease Involved in the Pathogenesis of Cells and the Release of S100 Proteins Are Monocyte-Induced Development of Th17. 2014; Available from: http://www.jimmunol.org/content/193/7/3355
Hughes TK, Wadsworth MH, Gierahn TM, Do T, Weiss D, Andrade PR, et al. Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Immunity. Cell Press; 2020;53(4):878-894.e7
Kovačić M, Mitrović-Ajtić O, Beleslin-Čokić B, Djikić D, Subotički T, Diklić M, et al. TLR4 and RAGE conversely mediate pro-inflammatory S100A8/9-mediated inhibition of proliferation-linked signaling in myeloproliferative neoplasms. Cellular Oncology. Springer Netherlands; 2018;41(5):541–553
Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, et al. The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells. Nature Medicine 2010 16:6. Nature Publishing Group; 2010;16(6):713–7 Available from: https://www.nature.com/articles/nm.2150
- Loss of S100A9 (MRP14) Results in Reduced Interleukin-8-Induced CD11b Surface Expression, a Polarized Microfilament System, and Diminished Responsiveness to Chemoattractants In Vitro. Molecular and Cellular Biology.American Society for Microbiology. 2003; 23: 1034-1043
Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, et al. The emerging role of IL-17 in the pathogenesis of psoriasis: Preclinical and clinical findings. Journal of Investigative Dermatology. Nature Publishing Group; 2013. p. 17–26
Mcinnes L, Healy J, Melville J. UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction. 2020
Nair RP, Callis Duffin K, Helms C, Ding J, Stuart PE, Goldgar D, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways. 2009
Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, et al. Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice. J Clin Invest. American Society for Clinical Investigation; 2012;122(6):2252–6 Available from: http://www.jci.org
Pruenster M, Vogl T, Roth J, Sperandio M. S100A8/A9: From basic science to clinical application. Pharmacol Ther. Pharmacol Ther; 2016;167:120–31 Available from: https://pubmed.ncbi.nlm.nih.gov/27492899/
- Increased expression of Wnt5a in psoriatic plaques. The Journal of investigative dermatology.J Invest Dermatol. 2007; 127: 163-169
Russell CB, Rand H, Bigler J, Kerkof K, Timour M, Bautista E, et al. Gene Expression Profiles Normalized in Psoriatic Skin by Treatment with Brodalumab, a Human Anti–IL-17 Receptor Monoclonal Antibody. The Journal of Immunology. The American Association of Immunologists; 2014;192(8):3828–3836
- S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3.Immunity. 2013; 39: 1171-1181
Shabani F, Farasat A, Mahdavi M, Gheibi N. Calprotectin (S100A8/S100A9): a key protein between inflammation and cancer. Inflammation Research. Birkhauser Verlag AG; 2018. p. 801–12
- Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. The Journal of investigative dermatology.J Invest Dermatol. 2012; 132: 2552-2564
- The S100A8/A9 heterodimer amplifies pro-inflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis.Arthritis Res Ther. 2006; 8
- DAMP Molecule S100A9 Acts as a Molecular Pattern to Enhance Inflammation during Influenza A Virus Infection: Role of DDX21-TRIF-TLR4-MyD88 Pathway.PLoS Pathog. 2014; 10
Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, et al. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. Journal of Clinical Investigation. American Society for Clinical Investigation; 2018;128(5):1852–1866
Wawrzycki B, Pietrzak A, Grywalska E, Krasowska D, Chodorowska G, Roliński J. Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis. Archivum Immunologiae et Therapiae Experimentalis. Springer; 2019;67(2):103
Wilsmann‐Theis D, Wagenpfeil J, Holzinger D, Roth J, Koch S, Schnautz S, et al. Among the S100 proteins, S100A12 is the most significant marker for psoriasis disease activity. Journal of the European Academy of Dermatology and Venereology. Blackwell Publishing Ltd; 2016;30(7):1165–1170 Available from: https://onlinelibrary.wiley.com/doi/10.1111/jdv.13269
- A Gene from a Psoriasis Susceptibility Locus Primes the Skin for Inflammation. Science translational medicine.NIH Public Access. 2010; 2: 61ra90
- Type I Interferon: Potential Therapeutic Target for Psoriasis? PLOS ONE.Public Library of Science. 2008; 3e2737
- The pro-apoptotic and pro-inflammatory effects of calprotectin on human periodontal ligament cells e110421. PLoS ONE.Public Library of Science. 2014; 9
Zimmer DB, Cornwall EH, Landar A, Song W. The S100 protein family: History, function, and expression. Brain Res Bull. Brain Res Bull; 1995;37(4):417–429 Available from: https://pubmed.ncbi.nlm.nih.gov/7620916/
Article info
Publication history
Publication stage
In Press Journal Pre-ProofFootnotes
Ribeirao Preto, Sao Paulo, Brazil.
CONFLICT OF INTEREST
The authors state no conflict of interest.
