January 2018 - Vol 138 No 1

Schematic showing the RAS/RAF/MEK pathway as well as the PI3K/AKT pathway.

Haugh and coworkers characterized acral melanocytic melanomas on dorsal, volar, and subungal/interdigital skin using next generation sequencing of a 50 gene panel. They detected mutation heterogeneity that may reflect differential UV exposure. See page 384 for details.