December 2018 — Vol 138 No 12

Model illustrating the physiological function of pyruvate underlying its protective role against cellular senescence. H3K9, histone H3 lysine 9; MCT, monocarboxylate transporter; MMP, mitochondrial membrane potential; NAD+, oxidized nicotinamide adenine dinucleotide; NADH, reduced nicotinamide adenine dinucleotide; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; RelA, NF-?B p65 subunit; ROS, reactive oxygen species; SASP, senescence-associated secretory phenotype; v-ATPase, vacuolar-type H+-ATPase.

Aging and metabolomics represent two hot topics that intersect in this month’s JID. Kim and colleagues report that supplemental pyruvate protects against age-associated phenotypes in human dermal fibroblast and human skin equivalents in vitro by increasing generation of NADþ associated with conversion of pyruvate to lactate. See the article on page 2522 for details.