August 2018 — Vol 138 No 8

Rapamycin suppresses tumor growth of in a murine BCC model.

Kim and coworkers implicate Hedgehog-regulated SOX9 and its downstream target mTOR in BCC pathogenesis. Administration of the mTOR inhibitor rapamycin attenuates UV-induced growth of tumors in Ptch1þ/ mice, a model that recapitulates some aspects of tumor growth in patients with basal cell nevus syndrome. See pages 1716-1725 for additional details