September 2018 — Vol 138 No 9

Mouse ears at days 0 and 15.Top row, IgG, bottom row, Anti-IL-23p19

The gain-of-function mutation Card14DE138 has been associated with severe psoriasis and pityriasis rubra pilaris in humans. Mellett and colleagues tested its pathogenicity by introducing Card14DE138 into mouse germline DNA via CRISPR technology. Murine “psoriasis” that shared features with human psoriasis resulted. Treatment of Card14DE138 heterozygous mice with anti-IL-23 p19 antibody attenuated disease (see figure). See the full article on page 2010.