December 2019 — Vol 139 No 12

B cells, antibodies, and ASC in the skin. (Left) Healthy, uninflamed skin. (Middle) Inflamed skin. (Right) Immunized skin.

The involvement of T cells in skin homeostasis and disease has been intensively studied for years. Recent interest in B-lineage cells is reflected in new insights that relate to the fundamental biology of skin antibody secreting cells (ASCs; plasma cells and plasmablasts), and that are reported and highlighted in two articles in this issue. See the Original Article by Wilson and colleagues (page 2477) and the related Commentary by Karsaalan and Tomayko (page 2411) for detailed information.