April 2019 — Vol 139 No 4

Images (taken from tumor top and bottom side) of DMSO-, myriocin-, or SKI-II–treated (a) MKL-1 tumors formed on the CAM (scale bar = 2 mm).

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine tumor that is resistantto conventional chemotherapy. Bhat and coworkers determined that serine palmitoyltransferase and sphingosine transferase inhibitors (myriocin and SKI-II respectively) limitedtumor size, invasion, and proliferation after inoculation of MC polyoma virusþMKL-1 cellsinto chorioallantoic membranes in vitro. See page 807 for more information about thisencouraging therapeutic approach.