May 2019 — Vol 139 No 5
Targeted inactivation of the gene encoding the transcription factor Fli1 in mouseendothelial cells causes a vasculopathy that mimics important features ofvasculopathy in systemic sclerosis patients. Yamashita used this mouse model(Fli1 ECKO mice) to assess effects of cyclophosphamide treatment on vascularstructure and function. Repeated administration of cyclophosphamide to Fli1ECKO mice attenuated arteriolar stenosis and other vessel structural abnormalities. See page 1150 for details..