January 2020 — Vol 140 No 1

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The importance of epigenetic mechanisms as regulators of epidermal homeostasis is increasingly appreciated. In this issue, an invited reviewfrom Köhler and Rodrı́guez-Paredes highlights the involvement of DNA methylation in epidermal differentiation, aging, and cancer (see pages 38-47). Ac, histone acetylation; CRC, chromatin remodeling complex;M, DNA methylation; Me, histone methylation.