November 2020 — Vol 140 No 11

Diagram illustrating Regulation of IGF1R endocytosis and recycling by two potential pathways.

Primary lesions of Merkel cell carcinoma contain variable numbers of tumor infiltrating T cells (TILs). Farah and coworkers characterized these TILs by assessing the heterogeneity and extent of representation of clonotypic T cell receptors. They determined that patients with abundant TILs that also exhibited clonal dominance (high Simpson’s Dominance index) had better outcomes than patients with few TILs and no dominant clones. Please see the article on page 2146 for the complete story.

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