December 2020 — Vol 140 No 12

The organization of MC territories. In the (a) absence versus (b) presence of inflammatory cues

In this issue of the JID, Di Nardo and Bradbury comment on original observations by Weitzmann and colleagues. Under steady state conditions, murine mast cell (MC) clonal colonies occupy stable nonoverlapping territories that are derived from centrally located progenitors that are of hematopoietic origin. In inflamed skin, bone marrow-derived progenitors infiltrate and produce MC clonal colonies that disrespect the boundaries of existing MC clonal colony territories. Read the relevant Original Article (pages 2433-2441) and Commentary (pages 2329-2331) for a detailed explanation.

Advertisement