April 2020 — Vol 140 No 4

Cartoon outlining the mixed-donor transplant strategy.

In this issue of the JID, Kubick and colleagues describe a new model that allowsreal time, in situ monitoring and assessment of cancer immunoediting ofkeratinocyte pre-cancers in syngeneic immunocompetent mice. Theinvestigators make use of transgenic mice that express mutant Κ-ras andendogenous fluorescent proteins (dsRED or EGFP) and that lack p53, coupledwith in vivo confocal fluorescence microscopy and skin transplantation ontoimmunocompromised and immunocompetent mice in their model system.See pages 891-900 for additional details.