July 2020 — Vol 140 No 7

 Immunofluorescence staining of vinculin (red) and actin (green) in keratinocytes stimulated with IL-17A or IL-17E for 24 hours. Nuclei were counterstained with DAPI (blue).

IL-17 family members have been convincingly implicated in psoriasispathogenesis, and therapies that target IL-17A are efficacious in patientswith psoriasis. In this issue of JID, Borowczyk et al demonstrate that IL-17Eenhances keratinocyte migration, here manifested by alterations in focaladhesion number and composition and cytoskeleton structure, ascompared with IL-17A and control treatment. See the full article on pages1379-1389 for details.