August 2020 — Vol 140 No 8

Diagram illustrating PAR2-TRPV3 signaling pathway in itch.

Recent insights into the pathogenesis and treatment of itch are exciting.In this issue, Zhao and colleagues implicate keratinocyte protease-activated receptor 2 (PAR2), acting via the warm temperature-sensitiveCa2þ-permeable cation channel TRPV3, in acute and chronic itch. Seepages 1531 for more information.