September 2020 — Vol 140 No 9

Diagram illustrating Regulation of IGF1R endocytosis and recycling by two potential pathways.

IGF1R signaling regulates several important aspects of keratinocyte physiology. In this issue, Dam and colleagues describe alternate pathways of insulin-like growth factor 1 receptor (IGF1R) endocytosis and recycling that are either Flotillin (Pathway 1)- or AP2A1/2 (Pathway 2)-dependent in normal primary human keratinocytes. See the Article on page 1743 for details.