January 2021 — Vol 141 No 1

Diagram showing Model: alpha3beta1 regulates secreted factors from tumor cells that promote a protumoral TME.

Longmate and coworkers utilize conditional inactivation of the a3 gene in epidermis to demonstrate that continuous α3β1 integrin expression by transformed keratinocytes is required for tumor maintenance. Expression of α3β1 also influences the composition of the keratinocyte secretome that participates in paracrine regulation of the tumor microenviroment (TME). See page 142 for more details. ECM; extracellular matrix