February 2021 — Vol 141 No 2

Diagram showing Immunohistochemical analysis of NEURL1 in Epi and SCCIS with a model of UV-induced SCCIS formation.

Zheng and coworkers used laser capture microdissection coupled with next generation DNA and RNA sequencing to identify mutations and assess gene expression in lesions of human SCCa in situ (right panels) as compared with adjacent UVR-exposed skin (left panels). Perturbation of NOTCH signaling pathways may occur early in human skin carcinogenesis. See pages 295e307 in this issue for more information.

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