March 2021 — Vol 141 No 3

Diagram showing canonical and noncanonical inflammasome activation pathways leads to IL-1beta production, resulting in plaque psoriasis and cardiometabolic comorbidities.

In a Commentary on an Original Article by Verma et al (pages 476–478), Contassot and French discuss the possibility that TNF antagonists may attenuate cardiometabolic comorbidities in patients with psoriasis by blocking TNF-dependent non-canonical activation of the inflammasome. See pages 586–595 for more information.