June 2022 — Vol 142 No 6

CTRP3 in psoriasis pathogenesis

Pseudoxanthoma elasticum (PXE) is a hereditary disorder associated with ectopic calcification affecting the skin, eyes, and blood vessels. Nollet and coworkers show that DNA damage response (DDR) signaling via PARP1 was increased in PXE fibroblasts with advancing ectopic calcification. Minocycline treatment attenuated DDR activation and PARP1 signaling and resulted in reduced aberrant mineralization in both PXE fibroblasts and the abcc6a‒/‒ zebrafish model of PXE. The authors suggest that minocycline represents a conceivable treatment option for this genodermatosis. For details see page 1629.