July 2022 — Vol 142 No 7

Model of fibroblast lineages, states, and fates for P0 neonatal skin

In this issue of the JID, Thompson and colleagues analyzed skin of newborn mice by single-cell Assay for Transposase-Accessible Chromatin sequencing and single-cell RNA sequencing in parallel. They report that accessible chromatin does not always translate to gene expression and that many fibroblast lineage markers reflect a fibroblast state, which includes neonatal papillary fibroblasts, reticular fibroblasts, and myofibroblasts (upper panel). Furthermore, their findings suggest that the chromatin landscapes of neonatal papillary and reticular fibroblasts are poised to differentiate into dermal papilla and adipocyte fates, respectively (lower panel). To learn more about the methods used and the experimental results see the article on page 1812.