Pemphigus & Pemphigoid
Higher Frequency of Dipeptidyl Peptidase-4 Inhibitor Intake in Bullous Pemphigoid Patients than in the French General Population
Dipeptidyl peptidase-4 inhibitors have been suspected to induce bullous pemphigoid (BP). The objective of this study was to compare the observed frequency of gliptin intake in a large sample of 1,787 BP patients diagnosed between 2012 and 2015 in France, with the expected frequency after indirect age standardization on 225,412 individuals extracted from the database of the National Healthcare Insurance Agency. The secondary objective was to assess the clinical characteristics and the course of gliptin-associated BP, depending on whether gliptin was continued or stopped.Incidence and Mortality of Pemphigus in France
The incidence of pemphigus varies from 0.5 to 34 cases/million inhabitants/year, with the highest incidence rates in Brazil (Hans-Filho et al., 1996; Ishii et al., 2008; Langan et al., 2008; Meyer and Misery, 2010). Additionally, although the prognosis of pemphigus patients is considered good in the literature, recent findings reported unusually high mortality rates (Almugairen et al., 2013; Langan et al., 2008).
