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Itch

In the special section on itch in the January 2022 issue, 4 invited Reviews and a Commentary provide a complementary introduction into the exciting and rapidly advancing field of itch research. Stemming from cutting-edge research in neuroscience, immunology, and skin biology, these advancements, which are concisely described in these articles, are already impacting patient care.

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Spotlight on Itch
Open Archive
Circuit Mechanisms of Itch in the Brain
Journal of Investigative Dermatology
Vol. 142Issue 1p23–30Published online: October 15, 2021
- Di Mu
- Yan-Gang Sun
Cited in Scopus: 8
Itch is an unpleasant somatic sensation with the desire to scratch, and it consists of sensory, affective, and motivational components. Acute itch serves as a critical protective mechanism because an itch-evoked scratching response will help to remove harmful substances invading the skin. Recently, exciting progress has been made in deciphering the mechanisms of itch at both the peripheral nervous system and the CNS levels. Key neuronal subtypes and circuits have been revealed for ascending transmission and the descending modulation of itch.

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Itch

Circuit Mechanisms of Itch in the Brain