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Original Article Melanocytes/Melanoma
Open Archive
Histologic and Phenotypic Factors and MC1R Status Associated with BRAF^V600E, BRAF^V600K, and NRAS Mutations in a Community-Based Sample of 414 Cutaneous Melanomas
Journal of Investigative Dermatology
Vol. 136Issue 4p829–837Published online: January 22, 2016
- Elke Hacker
- Catherine M. Olsen
- Marina Kvaskoff
- Nirmala Pandeya
- Abrey Yeo
- Adèle C. Green
- and others
Cited in Scopus: 23
Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes. To gain clearer insights into the factors contributing to somatic mutation genotypes in melanoma, we collected clinical and epidemiologic data, performed skin examinations, and collected saliva and tumor samples from a community-based series of 414 patients aged 18 to 79, newly diagnosed with cutaneous melanoma.