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Psoriasis
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- ReviewOpen Archive
Recent Highlights in Psoriasis Research
Journal of Investigative DermatologyVol. 137Issue 3p550–556Published online: January 4, 2017- Samuel T. Hwang
- Tamar Nijsten
- James T. Elder
Cited in Scopus: 46This article highlights recent advances in the immunology, epidemiology, and genetics/genomics of psoriasis. Advances sometimes generate more questions, and this article makes an attempt to point out where controversies might exist in the literature. Many of the articles mentioned were published in the Journal of Investigative Dermatology, but many articles from the broader scientific literature are also cited, to provide context and to add further validity for some of these key findings. Among the themes we explore are the identification of antigens in psoriasis, the co-morbidities of psoriasis, and novel integrative approaches to genome-wide association studies. - ReviewOpen Archive
One SNP at a Time: Moving beyond GWAS in Psoriasis
Journal of Investigative DermatologyVol. 136Issue 3p567–573Published online: January 22, 2016- Helen Ray-Jones
- Stephen Eyre
- Anne Barton
- Richard B. Warren
Cited in Scopus: 38Although genome-wide association studies have revealed important insights into the global genetic basis of psoriasis, the findings require further investigation. At present, the known genetic risk loci are largely uncharacterized in terms of the variant or gene responsible for the association, the biological pathway involved, and the main cell type driving the pathology. This review primarily focuses on current approaches toward gaining a complete understanding of how these known genetic loci contribute to an increased disease risk in psoriasis.