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    • Psoriasis
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    • Original Article Clinical Research: Therapeutics
      Open Access

      Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study

      Journal of Investigative Dermatology
      Vol. 139Issue 1p115–123Published online: August 18, 2018
      • Nina Wilkinson
      • Teresa Tsakok
      • Nick Dand
      • Karien Bloem
      • Michael Duckworth
      • David Baudry
      • and others
      Cited in Scopus: 46
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        Biologics have transformed management of inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by circulating drug levels has been proposed. We aimed to determine the real-world clinical utility of therapeutic drug monitoring in psoriasis. Within a multicenter (n = 60) prospective observational cohort, 544 psoriasis patients were included who were receiving adalimumab monotherapy and had at least one serum sample and Psoriasis Area and Severity Index (PASI) score available within the first year.
        Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study
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