We read with great interest the article by D’Erme et al. (2015) entitled “IL-36γ (IL-1F9) Is a Biomarker for Psoriasis Skin Lesions.” By performing an unsupervised gene cluster analysis, the authors identified genes specifically expressed within different subsets of inflammatory skin diseases; among these, psoriasis-associated genes were further analyzed to show that IL-36γ showed the strongest association with psoriasis when compared with the other skin diseases. The authors confirmed this specificity, showing high levels of IL-36γ both in skin by immunohistochemistry and in serum by ELISA assay.
