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- CommentaryOpen Archive
Psoriasis and Cardiovascular Risk: Strength in Numbers Part 3
Journal of Investigative DermatologyVol. 135Issue 9p2148–2150Published in issue: September, 2015- Alexis Ogdie
- Andrea B. Troxel
- Nehal N. Mehta
- Joel M. Gelfand
Cited in Scopus: 19Over the last decade a large body of epidemiological, translational, and animal model research has suggested that psoriasis may be a risk factor for cardiovascular and metabolic disease. Outcome based studies often suggest that patients with more severe psoriasis have an increased risk of major cardiovascular events independent of traditional risk factors that are captured in electronic health data. The study by Parisi and colleagues finds that incident severe psoriasis is associated with a non-statistically significant increased risk of major cardiovascular events, HR 1.28 (95% CI 0.96–1.69) in their primary model and a statistically significant increased risk, HR 1.46 (95% CI 1.11, 1.92), in a sensitivity analysis that excludes patients with inflammatory arthritis.
