Resources for Clinical Research in the JID
- Cost-effectiveness analysis (CEA) is a research method used to determine the clinical benefit-to-cost ratio of a given intervention. CEA offers a standardized means of comparing cost-effectiveness among interventions. Changes in quality-adjusted life-years, disability-adjusted life-years, or survival and mortality are some of the common clinical benefit measures incorporated into CEA. Because accounting for all associated costs and benefits of an intervention is complex and potentially introduces uncertainty into the analysis, sensitivity analyses can be performed to test the analytic model under varying conditions.
- Comparative effectiveness research (CER) aids clinicians faced with medical decision making by identifying the best strategies among a variety of available preventive, diagnostic, and treatment options. Differing from early-phase clinical trials—in which an intervention is compared with a placebo and assessed for efficacy—the goal of CER is to discriminate among clinical interventions on the basis of clinical effectiveness, cost-effectiveness, adverse effects, or other distinguishing factors.